Monday, December 21, 2020

Tozinameran[12] (INN), codenamed BNT162b2, and commonly known as the Pfizer–BioNTech COVID-19 vaccine, is a COVID-19 vaccine developed by BioNTech in cooperation with Pfizer. It i


msdogfood@hotmail.com


 Tozinameran[12] (INN), codenamed BNT162b2, and commonly known as the Pfizer–BioNTech COVID-19 vaccine, is a COVID-19 vaccine developed by BioNTech in cooperation with Pfizer. It is both the first COVID-19 vaccine to be authorized by a stringent regulatory authority for emergency use[13][14] and the first cleared for regular use.[11]


It is given by intramuscular injection. It is an RNA vaccine composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the spike protein of SARS-CoV-2, which is encapsulated in lipid nanoparticles.[15][16] The vaccination requires two doses given three weeks apart.[17][18][19] Its ability to prevent severe infection in children, pregnant women, or immune-compromised people is unknown, as is the duration of the immune effect it confers.[19][20][21]


Trials began in April 2020; by November, the vaccine had been tested on more than 40,000 people.[22] An interim analysis of study data showed a potential efficacy of over 90% in preventing infection within seven days of a second dose.[18][19] The most common side effects include mild to moderate pain at the injection site, fatigue, and headache.[23][24] As of December 2020, reports of serious side effects, such as allergic reactions, have been very rare,[a] and no long-term complications have been reported.[26]


In December 2020, tozinameran was under evaluation for emergency use authorization (EUA) for widespread use by several medical regulators globally. Emergency authorization is required as its Phase III clinical trials are still ongoing: monitoring of the primary outcomes will continue until August 2021, while monitoring of the secondary outcomes will continue until January 2023.[17] The United Kingdom was the first country to authorize its use on an emergency basis.[26] Other countries followed within a week.[5][27][28] By 16 December, 138,000 people in Britain had received the vaccine as part of the national vaccination programme.[29]


BioNTech is the initial developer of the vaccine, which partnered with Pfizer for the developing, logistics, finances, overseeing the clinical trials, and for worldwide manufacturing, with the exception of China where the license to distribute and manufacture was purchased by Fosun, alongside its investment in BioNTech.[30][31] Distribution to Germany and Turkey (likely due to origins of BioNTech's founders) is by BioNTech itself.[32] Pfizer indicated in November 2020, that 50 million doses could be available globally by the end of 2020, with about 1.3 billion doses in 2021.[19] Pfizer has advanced purchase agreements of about US$3 billion for providing a licensed vaccine in the United States, European Union, United Kingdom, Japan, Canada, Peru, and Mexico.[33] Distribution and storage of the vaccine is a global logistics challenge because it needs to be stored at temperatures between −80 and −60 °C (−112 and −76 °F),[34] until hours before vaccination.[33][34]



Contents

Development and funding

A vaccine for an infectious disease has never before been produced in less than several years, and no vaccine exists for preventing a coronavirus infection in humans.[35] After the coronavirus was detected in December 2019,[36] the genetic sequence of COVID‑19 was published on 11 January 2020, triggering an urgent international response to prepare for an outbreak and hasten development of a preventive vaccine.[37][38] In January 2020, German biotech-company BioNtech started its program 'Lightspeed' to develop a vaccine against the new COVID-19 virus based on its already established mRNA-technology.[22] Several variants of the vaccine were created in their laboratories in Mainz, and 20 of those were presented to experts of the Paul-Ehrlich-Institute in Langen.[39] Phase I / II Trials were started in Germany on 23 April 2020, and in the U.S. on 4 May 2020, with four vaccine candidates entering clinical testing. The Initial Pivotal Phase II / III Trial with the lead vaccine candidate 'BNT162b2' began in July. The Phase III results indicating a 95% effectiveness of the developed vaccine were published on 18 November 2020.[22]


BioNTech received a US$135 million investment from Fosun in March 2020 in exchange for 1.58 million shares in BioNTech and the future development and marketing rights of BNT162b2 in China,[31] Hong Kong, Macau and Taiwan.[40]


In September 2020, the German government granted BioNTech €375 million (US$445 million) for its COVID-19 vaccine development program at a time when Pfizer funded its portion of development costs without government funding.[41] BioNTech had also received €100 million (US$119 million) in financing from the European Commission and European Investment Bank, with the funding agreement finalized in June 2020.[42]


Pfizer CEO Albert Bourla stated that he decided against taking funding from the US government's Operation Warp Speed for the development of the vaccine "because I wanted to liberate our scientists [from] any bureaucracy that comes with having to give reports and agree how we are going to spend the money in parallel or together, etc." Pfizer did enter into an agreement with the US for the eventual distribution of the vaccine, as with other countries.[43]


Vaccine technology

See also: RNA vaccine and COVID-19 vaccine § Technology platforms

The BioNTech technology for the BNT162b2 vaccine is based on use of nucleoside-modified mRNA (modRNA) which encodes part of the spike protein found on the surface of the SARS-CoV-2 coronavirus (COVID-19), triggering an immune response against infection by the virus protein.[44]


The vaccine candidate BNT162b2 was chosen as the most promising among three others with similar technology developed by BioNTech.[17][44][45] Prior to choosing BNT162b2, BioNTech and Pfizer had conducted Phase I trials on BNT162b1 in Germany and the United States, while Fosun performed a Phase I trial in China.[16][46] In these Phase I studies, BNT162b2 was shown to have a better safety profile than the other three BioNTech candidates.[46]


Sequence

The modRNA sequence of tozinameran is 4,284 nucleotides long, with a molecular weight of approximately 1388 kDa.[47][48] It consists of a five-prime cap; a five prime untranslated region derived from the sequence of human alpha globin; a signal peptide coding region (bases 55–102); an optimized sequence which encodes a mutated version of the spike protein of SARS-CoV-2, containing two proline substitutions (K986P and V987P, designated "2P") that cause it to adopt a shape that stimulates neutralizing antibodies (bases 103-3879);[15][49] the three prime untranslated region (bases 3880–4174); and a poly(A) tail comprising 30 adenosine residues, a 10-nucleotide linker sequence, and 70 other adenosine residues (bases 4175-4284).[48] The sequence contains no uridine residues; it is replaced by 1-methyl-3′-pseudouridine.[48]


Composition

The vaccine contains the following inactive ingredients (excipients):[50][3]


ALC-0315 = ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)

ALC-0159 = 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)

cholesterol

dibasic sodium phosphate dihydrate

monobasic potassium phosphate

potassium chloride

sodium chloride

sucrose

water for injection

The first four of these are lipids. The lipids and modRNA together form nanoparticles. ALC-0159 is a polyethylene glycol conjugate (that is, a PEGylated lipid).[51]


The vaccine is supplied in a multidose vial as "a white to off-white, sterile, preservative-free, frozen suspension for intramuscular injection".[8][9] It must be thawed to room temperature and diluted with normal saline before administration.[9]


Clinical research

See also: COVID-19 vaccine § Clinical trials started in 2020

Preliminary results from Phase I–II clinical trials on BNT162b2, published in October 2020, indicated potential for its efficacy and safety.[15][45] During the same month, the European Medicines Agency (EMA) began a periodic review of BNT162b2.[52]


The study of BNT162b2 is a continuous-phase trial in Phase III as of November 2020.[17] It is a "randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals".[17] The early-stage research on BNT162b2 determined the safety and dose level for two vaccine candidates, with the trial expanding during mid-2020 to assess efficacy and safety of BNT162b2 in greater numbers of participants, reaching tens of thousands of people receiving test vaccinations in multiple countries in collaboration with Pfizer and Fosun.[19][31]


The Phase III trial assesses the safety, efficacy, tolerability, and immunogenicity of BNT162b2 at a mid-dose level (two injections separated by 21 days) in three age groups: 12–15 years, 16–55 years or above 55 years.[17]


The ongoing Phase III trial, which is scheduled to run from 2020 to 2022, is designed to assess the ability of BNT162b2 to prevent severe infection, as well as the duration of immune effect.[19][20][21] Side effects include serious allergic reaction in those susceptible,[53] aches and fever.[19]


Authorizations

Expedited

The United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) gave the vaccine "rapid temporary regulatory approval to address significant public health issues such as a pandemic" on 2 December 2020, which it is permitted to do under the 1968 Medicines Act.[54] It was the first COVID-19 vaccine to be approved for national use after undergoing large scale trials,[55] and the first mRNA vaccine to be authorized for use in humans.[13][56] The United Kingdom thus became the first Western country to approve a COVID-19 vaccine for national use,[57] although the decision to fast-track the vaccine was criticised by some experts.[58] On 8 December 2020, Margaret "Maggie" Keenan, 90, from Fermanagh, became the first person to receive the vaccine in the UK.[59] By 16 December, 138,000 British residents had received the vaccine as part of the national vaccination programme.[29]


In December, after the United Kingdom, the following countries expedited processes to approve the Pfizer-BioNTech COVID-19 vaccine for use: Bahrain,[60] Canada,[61][62] Mexico,[63] the United States,[7] Kuwait,[64] Singapore,[65] Jordan,[66] Oman,[67] Saudi Arabia, Ecuador, and Chile.[68][69][28]


In the United States, an emergency use authorization (EUA) is "a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic", according to the FDA.[70] Following an EUA issuance, BioNTech-Pfizer are expected to continue the Phase III clinical trial to finalize safety and efficacy data, leading to application for licensure (approval) of the vaccine in the United States.[70][71][72] The United States Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) approved recommendations for vaccination of those aged 16 years or older.[73][74]


Standard

On 19 December 2020, the Swiss Agency for Therapeutic Products (Swissmedic) approved the Pfizer-BioNTech COVID-19 vaccine for regular use, two months after receiving the application, stating that the vaccine fully complied with the requirements of safety, efficacy and quality. This is the first authorization under a standard procedure, as Swiss laws do not allow emergency approvals.[1][75]


On December 21, 2020, the European Medicines Agency (EMA) recommended granting conditional marketing authorization for tozinameran.[76][2] The recommendation was accepted by the European Commission shortly thereafter, with EMA director Emer Cooke confirming that despite the "conditional" qualifier, the vaccine was granted full authorization rather than for emergency or temporary use.[77]


Adverse events

As a result of two vaccinees who had severe anaphylactic reactions, the UK's MHRA advised on 9 December 2020 that people who have a history of "significant" allergic reaction should not receive the Pfizer-BioNTech COVID-19 vaccine.[78][79][80] On 12 December, the Canadian regulator followed suit, noting that: "Both individuals in the U.K. had a history of severe allergic reactions and carried adrenaline auto injectors. They both were treated and have recovered."[50]


As of 18 December, the US CDC stated that in their jurisdiction six cases of "severe allergic reaction" had been recorded from more than 250,000 vaccinations, and of those six only one person had a "history of vaccination reactions".[81]


Manufacturing

Pfizer is manufacturing the vaccine in its own facilities in a three-stage process. The first stage, conducted at a small pilot plant in St. Louis, involves the molecular cloning of DNA plasmids that code for the spike protein by infusing them into Escherichia coli bacteria. After four days of growth, the bacteria are killed and broken open, and the contents of their cells are purified over a week and a half to recover the desired DNA product. The DNA is stored in tiny bottles and frozen for shipment. Safely and quickly transporting the DNA at this stage is so important that Pfizer has used its company jet and helicopter to assist.[82]


The second stage is being conducted at plants in Andover, Massachusetts, and in Germany. The DNA is used as a template to build the desired mRNA strands. Once the mRNA has been created and purified, it is frozen in plastic bags about the size of a large shopping bag, of which each can hold up to 5 to 10 million doses. The bags are placed on special racks on trucks which take them to the next plant.[82]


The third stage is being conducted at plants in Kalamazoo, Michigan, and Puurs, Belgium. This stage involves combining the mRNA with lipid nanoparticles, then filling vials, boxing vials, and freezing them.[82] Croda International subsidiary Avanti Polar Lipids is providing the requisite lipids.[83] As of mid-November 2020, the major bottleneck in the manufacturing process was combining mRNA with lipid nanoparticles.[82]


Advance orders and logistics

See also: COVID-19 vaccine § Supply chain

The first doses of the vaccine in December 2020 are being manufactured at a Pfizer-owned production plant in Puurs, Belgium.[84]


Pfizer indicated in its 9 November press release that 50 million doses could be available by the end of 2020, with about 1.3 billion doses provided globally by 2021.[19] In July 2020, the vaccine development program Operation Warp Speed had placed an advance order of US$2 billion with Pfizer to manufacture 100 million doses of a COVID-19 vaccine for use in the United States if the vaccine is shown to be safe and effective.[85][86][87] On 9 November, the Pfizer-BioNTech partnership announced that the company is a supplier of a COVID-19 vaccine if proven to be successful and licensed.[30]


Pfizer also has agreements to supply 300 million doses to the European Union,[88] 120 million doses to Japan,[89] 40 million doses (10 million before 2021) to the United Kingdom,[21] 20 million doses to Canada,[90] and 34.4 million doses to Mexico.[91] Fosun also has agreements to supply 10 million doses to Hong Kong and Macau.[92] The Hong Kong government said it would receive its first batch of one million doses by the first quarter of 2021.[93]


BioNTech and Fosun agreed to supply Mainland China with a batch of 100 million doses in 2021, subject to regulatory approval. The initial supply will be delivered from BioNTech's production facilities in Germany.[94]


In total, only affluent countries have preorder agreements with Pfizer in 2020, and even those countries have meager or non-existent cold chain capacity for ultracold transport and storage of a vaccine that degrades within five days when thawed, and requires two shots three weeks apart.[33] The vaccine needs to be stored and transported at ultracold temperatures between −80 and −60 °C (−112 and −76 °F).[34][21][33][95][96] The head of Indonesia's Bio Farma Honesti Basyir stated that purchasing the vaccine is out of the question for the world's fourth-most populous country, given that it did not have the necessary cold chain capability. Similarly, India's existing cold chain network can only handle temperatures between 2 and 8 °C (36 and 46 °F), far above the requirements of the vaccine.[97][98]


References

 According to the British National Formulary, "very rare" applies when side effects occur in less than 1 in 10,000 instances.[25]

 "Swissmedic grants authorisation for the first COVID-19 vaccine in Switzerland" (Press release). Swiss Agency for Therapeutic Products (Swissmedic). 19 December 2020. Retrieved 19 December 2020.

 "Comirnaty: Pending EC decision". European Medicines Agency (EMA). 21 December 2020. Retrieved 21 December 2020.

 https://www.ema.europa.eu/en/documents/product-information/comirnaty-product-information-approved-chmp-21-december-2020-pending-endorsement-european-commission_en.pdf

 "Regulatory Decision Summary - Pfizer-BioNTech COVID-19 Vaccine". Health Canada. 9 December 2020. Retrieved 13 December 2020.

 "Regulatory Decision Summary - Pfizer-BioNTech COVID-19 Vaccine". Health Canada. 9 December 2020. Archived from the original on 9 December 2020. Retrieved 9 December 2020.

 "Regulatory approval of Pfizer / BioNTech vaccine for COVID-19". Medicines and Healthcare products Regulatory Agency (MHRA). 2 December 2020. Retrieved 2 December 2020.

 "FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine" (Press release). U.S. Food and Drug Administration (FDA). 11 December 2020. Retrieved 11 December 2020.  This article incorporates text from this source, which is in the public domain.

 "Pfizer-BioNTech COVID-19 Vaccine- rna ingredient bnt-162b2 injection, suspension". DailyMed. Retrieved 14 December 2020.

 Pfizer-BioNTech COVID-19 Vaccine Emergency Use Authorization Review Memorandum (PDF). U.S. Food and Drug Administration (FDA) (Report). 14 December 2020. Retrieved 14 December 2020.  This article incorporates text from this source, which is in the public domain.

 "Statement by President von der Leyen on the marketing authorisation of the BioNTech-Pfizer vaccine against COVID-19". European Commission. Retrieved 21 December 2020.

 "Swissmedic autorise un premier vaccin contre le coronavirus" (in French). Le Temps. 19 December 2020. Retrieved 19 December 2020.

 World Health Organization (2020). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 124 – COVID-19 (special edition)" (PDF). WHO Drug Information. 34 (3): 666. Archived (PDF) from the original on 27 November 2020. Retrieved 23 November 2020.

 "UK medicines regulator gives approval for first UK COVID-19 vaccine" (Press release). Medicines and Healthcare products Regulatory Agency (MHRA). 2 December 2020. Retrieved 2 December 2020.

 Boseley, Sarah; Halliday, Josh (2 December 2020). "UK approves Pfizer/BioNTech Covid vaccine for rollout next week". The Guardian. Retrieved 14 December 2020.

 Walsh EE, Frenck RW, Falsey AR, et al. (October 2020). "Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates". The New England Journal of Medicine. 383 (25): 2439–2450. doi:10.1056/NEJMoa2027906. PMC 7583697. PMID 33053279. Invalid |display-authors=6 (help)

 Walsh EE, Frenck R, Falsey AR, et al. (August 2020). "RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study". MedRxiv: 2020.08.17.20176651. doi:10.1101/2020.08.17.20176651. PMC 7444302. PMID 32839784. Invalid |display-authors=6 (help)

 Clinical trial number NCT04368728 for "NCT04368728: Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals" at ClinicalTrials.gov

 Palca J (9 November 2020). "Pfizer says experimental COVID-19 vaccine is more than 90% effective". NPR. Archived from the original on 9 November 2020. Retrieved 9 November 2020.

 Herper M (9 November 2020). "Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate". STAT. Archived from the original on 9 November 2020. Retrieved 9 November 2020.

 Edwards E (9 November 2020). "Pfizer's Covid-19 vaccine promising, but many questions remain". NBC News. Archived from the original on 22 November 2020. Retrieved 12 November 2020.

 Gallagher J (9 November 2020). "Covid vaccine: First 'milestone' vaccine offers 90% protection". BBC News. Archived from the original on 26 November 2020. Retrieved 9 November 2020.

 "Update on our COVID-19 vaccine development program with BNT162b2" (PDF) (Press release). Mainz, Germany: BioNTech. 2 December 2020. Retrieved 12 December 2020.

 Polack FP, Thomas SJ, Kitchin N, et al. (December 2020). "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine". N Engl J Med. doi:10.1056/NEJMoa2034577. PMID 33301246.

 "Questions and Answers About Pfizer-BioNTech COVID-19 Vaccine". Pfizer. Retrieved 16 December 2020.

 "Adverse reactions to drugs". British National Formulary. Retrieved 19 December 2020.

 "Coronavirus vaccine". National Health Service. 7 December 2020. Archived from the original on 7 December 2020. Retrieved 7 December 2020.

 "Bahrain becomes second country to approve Pfizer COVID-19 vaccine". Al Jazeera. Archived from the original on 4 December 2020. Retrieved 5 December 2020. 

* "Coronavirus: Saudi Arabia approves Pfizer COVID-19 vaccine for use". Al Arabiya English. 10 December 2020. Archived from the original on 11 December 2020. Retrieved 10 December 2020. 

* Daina Beth Solomon; Torres, Noe (11 December 2020). "Mexico approves emergency use of Pfizer's COVID-19 vaccine". Reuters. Retrieved 12 December 2020. 

* Thomas K (20 November 2020). "F.D.A. Clears Pfizer Vaccine, and Millions of Doses Will Be Shipped Right Away". The New York Times. Archived from the original on 12 December 2020. Retrieved 11 December 2020.

* "First shipments of Pfizer-BioNTech vaccine in Singapore by end-Dec; enough vaccines for all by Q3 2021". The Straits Times. 14 December 2020. Retrieved 14 December 2020.

 Yasmena Al Mulla (13 December 2020). "Kuwait approves emergency use of Pfizer vaccine". Gulf News. Retrieved 14 December 2020.

 Campbell D (16 December 2020). "138,000 people in UK receive Covid vaccine in first week". The Guardian.

 Thomas K, Gelles D, Zimmer C (9 November 2020). "Pfizer's early data shows vaccine is more than 90% effective". The New York Times. Archived from the original on 23 November 2020. Retrieved 9 November 2020.

 Burger L (15 March 2020). "BioNTech in China alliance with Fosun over coronavirus vaccine candidate". Reuters. Archived from the original on 14 November 2020. Retrieved 10 November 2020.

 "Pfizer and BioNTech Celebrate Historic First Authorization in the U.S. of Vaccine to Prevent COVID-19". Pfizer Inc. and BioNTech SE.

 "Deep-freeze hurdle makes Pfizer's vaccine one for the rich". Bloomberg. 10 November 2020. Archived from the original on 22 November 2020. Retrieved 12 November 2020. Vaccine goes bad five days after thawing, requires two shots; Many nations face costly ramp up of cold-chain infrastructure

 "Pfizer-BioNTech COVID-19 Vaccine Vaccination Storage & Dry Ice Safety Handling". Pfizer. Retrieved 17 December 2020.

 Gates B (30 April 2020). "The vaccine race explained: What you need to know about the COVID-19 vaccine". The Gates Notes. Archived from the original on 14 May 2020. Retrieved 2 May 2020.

 "World Health Organization timeline – COVID-19". World Health Organization. 27 April 2020. Archived from the original on 29 April 2020. Retrieved 2 May 2020.

 Thanh Le T, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M, et al. (9 April 2020). "The COVID-19 vaccine development landscape". Nature Reviews Drug Discovery. 19 (5): 305–06. doi:10.1038/d41573-020-00073-5. ISSN 1474-1776. PMID 32273591.

 Fauci AS, Lane HC, Redfield RR (March 2020). "Covid-19: Navigating the uncharted". The New England Journal of Medicine. 382 (13): 1268–69. doi:10.1056/nejme2002387. PMC 7121221. PMID 32109011.

 Papadopoulos C (14 December 2020). "Chronologie - So entstand der Corona-Impfstoff von Biontech" [Chronology - That's how the Covid-vaccine of Biontech was being developed] (in German). Stuttgart, Germany: Südwestrundfunk. Retrieved 20 December 2020.

 《Fosun Pharma and BioNTech form COVID-19 vaccine strategic alliance in China》(Fosun Phrama News Content , 15 March 2020)

 "BioNTech gets $445 million in German funding for vaccine". Bloomberg.com. 15 September 2020. Archived from the original on 9 November 2020. Retrieved 10 November 2020.

 "Germany: Investment Plan for Europe – EIB to provide BioNTech with up to €100 million in debt financing for COVID-19 vaccine development and manufacturing". European Investment Bank. 11 June 2020. Archived from the original on 9 November 2020. Retrieved 10 November 2020.

 "Pfizer CEO says he would've released vaccine data before election if possible". Axios. 9 November 2020. Archived from the original on 10 November 2020. Retrieved 11 November 2020.

 Gaebler C, Nussenzweig MC (October 2020). "All eyes on a hurdle race for a SARS-CoV-2 vaccine". Nature. 586 (7830): 501–2. doi:10.1038/d41586-020-02926-w. PMID 33077943. S2CID 224808629.

 Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. (October 2020). "Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults". Nature. 586 (7830): 589–593. doi:10.1038/s41586-020-2639-4. PMID 32785213. S2CID 221126922.

 "China's Fosun to end BioNTech's COVID-19 vaccine trial, seek approval for another". Reuters. 3 November 2020. Archived from the original on 12 December 2020. Retrieved 21 November 2020.

 World Health Organization. "INN: Tozinameran". WHO MedNet. Retrieved 1 December 2020.

 World Health Organization. "Messenger RNA encoding the full-length SARS-CoV-2 spike glycoprotein" (DOC). WHO MedNet. Retrieved 16 December 2020.

 Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, et al. (August 2017). "Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen". Proceedings of the National Academy of Sciences of the United States of America. 114 (35): E7348–E7357. doi:10.1073/pnas.1707304114. PMC 5584442. PMID 28807998.

 "Pfizer-BioNTech COVID-19 vaccine: Health Canada recommendations for people with serious allergies". Health Canada. 12 December 2020.

 "Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection" (PDF). Regulation 174. MHRA. 15 December 2020.

 Hannah B (7 October 2020). "EMA begins rolling review of BNT162b2 COVID-19 vaccine". European Pharmaceutical Review. Archived from the original on 11 November 2020. Retrieved 11 November 2020.

 Tiggle N (9 December 2020). " Covid-19 vaccine: Allergy warning over new jab". BBC News. Archived from the original on 9 December 2020. Retrieved 9 December 2020.

 "UK medicines regulator gives approval for first UK COVID-19 vaccine". Medicines and Healthcare products Regulatory Agency (MHRA). 2 December 2020. Archived from the original on 2 December 2020. Retrieved 2 December 2020.

 Neergaard L, Kirka D (2 December 2020). "Britain OKs Pfizer vaccine and will begin shots within days". AP. Archived from the original on 6 December 2020. Retrieved 6 December 2020.

 Mueller B (2 December 2020). "U.K. Approves Pfizer Coronavirus Vaccine, a First in the West". The New York Times. Retrieved 2 December 2020.

 Roberts M (2 December 2020). "Covid Pfizer vaccine approved for use next week in UK". BBC News Online. Archived from the original on 2 December 2020. Retrieved 2 December 2020.

 Henley J, Connolly K, Jones S (3 December 2020). "European and US experts question UK's fast-track of Covid vaccine". The Guardian. Archived from the original on 9 December 2020. Retrieved 9 December 2020.

 "First patient receives Pfizer Covid-19 vaccine". 8 December 2020. Archived from the original on 8 December 2020. Retrieved 8 December 2020 – via www.bbc.co.uk.

 "Bahrain becomes second country to approve Pfizer COVID-19 vaccine". Al Jazeera. Retrieved 5 December 2020.

 "Pfizer-BioNTech COVID-19 Vaccine (tozinameran)". Government of Canada. 16 December 2020.

 "Drug and vaccine authorizations for COVID-19: List of applications received". Health Canada. 9 December 2020. Retrieved 9 December 2020.

 "Mexico Approves Pfizer Vaccine for Emergency Use as Covid Surges". Bloomberg. 12 December 2020. Retrieved 12 December 2020.

 "Kuwait authorizes emergency use of Pfizer-BioNTech COVID-19 vaccine". Arab News. 13 December 2020. Retrieved 15 December 2020.

 "Singapore approves use of Pfizer's COVID-19 vaccine". AP News. 14 December 2020. Retrieved 15 December 2020.

 "Jordan approves Pfizer-BioNTech Covid vaccine". France 24. 15 December 2020. Retrieved 15 December 2020.

 "Oman issues licence to import Pfizer BioNTech Covid vaccine - TV". Reuters. 15 December 2020. Retrieved 16 December 2020.

 "Chile y Ecuador se adelantan en Sudamérica y autorizan la vacuna de Pfizer". El Pais. Retrieved 17 December 2020.

 "Saudi Arabia to Launch Its Coronavirus Vaccination Program" (in Spanish). Boomberg. Retrieved 17 December 2020.

 "Emergency Use Authorization for vaccines explained". U.S. Food and Drug Administration (FDA). 20 November 2020. Archived from the original on 20 November 2020. Retrieved 20 November 2020.  This article incorporates text from this source, which is in the public domain.

 "Pfizer-BioNTech COVID-19 Vaccine EUA Letter of Authorization" (PDF). U.S. Food and Drug Administration (FDA). 11 December 2020.  This article incorporates text from this source, which is in the public domain.

 "Pfizer-BioNTech COVID-19 Vaccine EUA Fact Sheet for Healthcare Providers" (PDF). Pfizer. 11 December 2020.

 Sun LH, Stanley-Becker I. "CDC greenlights advisory group's decision to recommend Pfizer vaccine for use". The Washington Post. Retrieved 14 December 2020.

 "The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine — United States, December 2020" (PDF). MMWR. 69. December 2020.

 "COVID-19: Switzerland can start vaccinating vulnerable groups already in December" (Press release). Federal Office of Public Health. 19 December 2020. Retrieved 19 December 2020.

 "EMA recommends first COVID-19 vaccine for authorisation in the EU". European Medicines Agency (EMA) (Press release). 21 December 2020. Retrieved 21 December 2020.

 Mezher, Michael (21 December 2020). "EU authorizes Pfizer-BioNTech COIVD vaccine". Regulatory Affairs Professionals Society. Retrieved 21 December 2020.

 Bostock N (9 December 2020). "MHRA warning after allergic reactions in NHS staff given COVID-19 vaccine". GP. Archived from the original on 9 December 2020. Retrieved 9 December 2020.

 Booth, William; Cunningham, Erin (9 December 2020). "Britain warns against Pfizer vaccine for people with history of 'significant' allergic reactions". The Washington Post. Archived from the original on 9 December 2020. Retrieved 9 December 2020.

 Cabanillas, Beatriz; Akdis, Cezmi; Novak, Natalija (2020). "Allergic reactions to the first COVID‐19 vaccine: A potential role of Polyethylene glycol?". Allergy. doi:10.1111/all.14711. PMID 33320974. S2CID 229284320.

 FURTULA, ALEKSANDAR; JORDANS, FRANK (21 December 2020). "EU regulator gives conditional approval to Pfizer-BioNTech COVID-19 vaccine". The Globe and Mail Inc. Reuters.

 Johnson, Carolyn Y. (17 November 2020). "A vial, a vaccine and hopes for slowing a pandemic — how a shot comes to be". The Washington Post. Washington, D.C.: WP Company LLC. Retrieved 21 December 2020.

 Mullin, Rick (25 November 2020). "Pfizer, Moderna ready vaccine manufacturing networks". Chemical & Engineering News. Washington, D.C.: American Chemical Society. Retrieved 21 December 2020.

 "First doses of Pfizer-BioNTech Covid-19 vaccine being shipped from Belgium to Britain". The Straits Times. 3 December 2020. Archived from the original on 9 December 2020. Retrieved 8 December 2020.

 Erman M, Ankur B (22 July 2020). "U.S. to pay Pfizer, BioNTech $1.95 bln for millions of COVID-19 vaccine doses". Reuters. Archived from the original on 22 July 2020. Retrieved 22 July 2020.

 "U.S. Government Engages Pfizer to Produce Millions of Doses of COVID-19 Vaccine". US Department of Health and Human Services. 22 July 2020. Archived from the original on 22 July 2020. Retrieved 23 July 2020.

 Nazaryan A (9 November 2020). "So is Pfizer part of Operation Warp Speed or not? Yes and no". Yahoo Financial News. Archived from the original on 10 November 2020. Retrieved 9 November 2020.

 Pleitgen F (11 November 2020). "EU agrees to buy 300 million doses of the Pfizer/BioNTech Covid-19 vaccine". CNN. Archived from the original on 24 November 2020. Retrieved 26 November 2020.

 "Japan and Pfizer reach COVID-19 vaccine deal to treat 60 million people". The Japan Times. 1 August 2020. Archived from the original on 10 November 2020. Retrieved 21 November 2020.

 Tasker JP (9 November 2020). "Trudeau says promising new Pfizer vaccine could be 'light at the end of the tunnel'". CBC News. Archived from the original on 9 November 2020. Retrieved 9 November 2020.

 Salud Sd. "233. Firma secretario de Salud convenio con Pfizer para fabricación y suministro de vacuna COVID-19". gob.mx (in Spanish). Retrieved 17 December 2020.

 Ng E (27 August 2020). "Fosun Pharma to supply Covid-19 vaccine to Hong Kong, Macau once approved". South China Morning Post. Archived from the original on 20 November 2020. Retrieved 21 November 2020.

 Ting, Victor; Lau, Chris; Wong, Olga (11 December 2020). "Hong Kong buys 15 million Covid-19 vaccine doses from Sinovac, Pfizer". South China Morning Post. Retrieved 18 December 2020.

 "BioNTech and Fosun Pharma to Supply China with mRNA-based COVID-19 Vaccine" (Press release). BioNTech. 16 December 2020. Retrieved 16 December 2020.

 Kollewe J. "Pfizer and BioNTech's vaccine poses global logistics challenge". The Guardian. Archived from the original on 10 November 2020. Retrieved 10 November 2020.

 Newey S (8 September 2020). "Daunting task of distribution exposed as it emerges some vaccines must be 'deep frozen' at −70C". The Telegraph. Archived from the original on 9 November 2020. Retrieved 10 November 2020.

 "How China's COVID-19 could fill the gaps left by Pfizer, Moderna, AstraZeneca". Fortune. 5 December 2020. Archived from the original on 12 December 2020. Retrieved 5 December 2020.

 "Pfizer's Vaccine Is Out of the Question as Indonesia Lacks Refrigerators: State Pharma Boss". Jakarta Globe. 22 November 2020. Archived from the original on 7 December 2020. Retrieved 5 December 2020.

External links

Scholia has a profile for tozinameran (Q97154240).

"Tozinameran". Drug Information Portal. U.S. National Library of Medicine.

Global Information About Pfizer‑BioNTech COVID‑19 Vaccine (also known as BNT162b2)

A phase 1/2/3, placebo-controlled, randomized, observer-blind, dose-finding study to evaluate the safety, tolerability, immunogenicity, and efficacy of SARS-COV-2 RNA vaccine candidates against COVID`-19 in healthy individuals Original study protocol (by Pfizer)

Pfizer and BioNTech Announce Vaccine Candidate Against COVID-19 Achieved Success in First Interim Analysis from Phase 3 Study(press release by Pfizer, 2020-11-09)

Information for UK Healthcare Professionals on COVID-19 mRNA Vaccine BNT162b2 concentrate for solution for injection

vte

COVID-19 pandemic



Sunday, December 20, 2020

COVID-19 vaccine 12/20 2020.



msdogfood@hotmail.com

COVID-19 vaccine



 A COVID‑19 vaccine is a vaccine intended to provide acquired immunity against COVID-19. Prior to the COVID-19 pandemic, work to develop a vaccine against the coronavirus diseases SARS and MERS had established knowledge about the structure and function of coronaviruses, which accelerated development during early 2020 of varied technology platforms for a COVID‑19 vaccine.


By mid-December 2020, 57 vaccine candidates were in clinical research, including 40 in Phase I–II trials and 17 in Phase II–III trials. In November 2020, BioNTech and Pfizer Inc, Moderna, the University of Oxford (in collaboration with AstraZeneca), and the Gamaleya Institute announced positive results from interim analyses of their Phase III vaccine trials.


As of 19 December, 16 countries[b] had approved tozinameran, the Pfizer–BioNTech vaccine, for emergency use. Bahrain gave emergency marketing authorization for the vaccine manufactured by Sinopharm,[2] followed by the United Arab Emirates.[3] In the United Kingdom, 138,000 people had received tozinameran by 16 December during the first week of the UK vaccination programme.[17] On 11 December 2020, the United States Food and Drug Administration (FDA) granted an emergency use authorization (EUA) for tozinameran.[18] A week later, they granted an EUA for mRNA-1273, the Moderna vaccine, making the United States the first country to authorize two vaccines for public use.[19][20]


By December, more than 10 billion vaccine doses had been preordered by countries,[21] with about half of the doses purchased by high-income countries comprising only 14% of the world's population.[22] The manufacturers of three vaccines closest to global distribution – Pfizer, Moderna, and AstraZeneca – predicted a manufacturing capacity of 5.3 billion doses in 2021, which could be used to vaccinate about 3 billion people (as the vaccines require two doses for a protective effect against COVID-19). Due to the high demand of preorders in 2020–21,[22] people in low-income developing countries may not receive vaccinations from these manufacturers until 2023 or 2024, increasing the need for the global COVAX initiative to supply vaccines equitably.[21][22]



Contents

Synopsis and history

SARS and MERS

Vaccines have been produced against several animal diseases caused by coronaviruses, including as of 2003 infectious bronchitis virus in birds, canine coronavirus, and feline coronavirus.[23] Previous projects to develop vaccines for viruses in the family Coronaviridae that affect humans have been aimed at severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Vaccines against SARS[24] and MERS[25] have been tested in non-human animals.


According to studies published in 2005 and 2006, the identification and development of novel vaccines and medicines to treat SARS was a priority for governments and public health agencies around the world at that time.[26][27][28] As of 2020, there is no cure or protective vaccine proven to be safe and effective against SARS in humans.[29][30]


There is also no proven vaccine against MERS.[31] When MERS became prevalent, it was believed that existing SARS research may provide a useful template for developing vaccines and therapeutics against a MERS-CoV infection.[29][32] As of March 2020, there was one (DNA based) MERS vaccine which completed Phase I clinical trials in humans,[33] and three others in progress, all of which are viral-vectored vaccines: two adenoviral-vectored (ChAdOx1-MERS, BVRS-GamVac), and one MVA-vectored (MVA-MERS-S).[34]


COVID‑19 vaccine development in 2020

A vaccine for an infectious disease has never before been produced in less than several years, and no vaccine exists for preventing a coronavirus infection in humans.[35] After the coronavirus was detected in December 2019,[36] the genetic sequence of COVID‑19 was published on 11 January 2020, triggering an urgent international response to prepare for an outbreak and hasten development of a preventive vaccine.[37][38][39]


In February 2020, the World Health Organization (WHO) said it did not expect a vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus, to become available in less than 18 months.[40] The rapidly growing infection rate of COVID‑19 worldwide during early 2020 stimulated international alliances and government efforts to urgently organize resources to make multiple vaccines on shortened timelines,[41] with four vaccine candidates entering human evaluation in March (see the table of clinical trials started in 2020, below).[37][42]


In April 2020, the WHO estimated a total cost of US$8 billion to develop a suite of three or more vaccines having different technologies and distribution.[41]


By April 2020, "almost 80 companies and institutes in 19 countries" were working on this virtual gold rush.[43] Also in April, CEPI estimated that as many as six of the vaccine candidates against COVID‑19 should be chosen by international coalitions for development through Phase II–III trials, and three should be streamlined through regulatory and quality assurance for eventual licensing at a total cost of at least US$2 billion.[44][42][35] Another analysis estimates 10 candidates will need simultaneous initial development, before a select few are chosen for the final path to licensing.[35]


In July 2020, Anglo-American intelligence and security organisations of the respective governments and armed forces, as the UK's National Cyber Security Centre, together with the Canadian Communications Security Establishment, the United States Department for Homeland Security Cybersecurity Infrastructure Security Agency, and the US National Security Agency (NSA) alleged that Russian state-backed hackers may have been trying to steal COVID‑19 treatment and vaccine research from academic and pharmaceutical institutions in other countries; Russia has denied it.[45]


Global development

During 2020, major changes in the overall effort of developing COVID‑19 vaccines since early in the year have been the increasing number of collaborations of the multinational pharmaceutical industry with national governments, and the diversity and growing number of biotechnology companies in many countries focusing on a COVID-19 vaccine.[44] According to CEPI, the general geographic distribution of COVID‑19 vaccine development involves organizations in North America having about 40% of the world's COVID-19 vaccine research, compared with 30% in Asia and Australia, 26% in Europe, and a few projects in South America and Africa.[44][37]


Access to COVID-19 Tools (ACT) Accelerator and COVAX

A multinational collaboration, including the World Health Organization (WHO), the Coalition for Epidemic Preparedness Innovations (CEPI), GAVI, the Gates Foundation, and governments, formed the Access to COVID-19 Tools (ACT) Accelerator, to raise financial support of accelerated research and development, production, and globally-equitable access to COVID-19 tests, therapies, and licensing of vaccines, which are in a specific development program called the "COVAX Pillar".[46][47] The COVAX Pillar has the goal of facilitating licensure of several COVID-19 vaccines, influencing equitable pricing, and providing equal access for up to 2 billion doses by the end of 2021 to protect frontline healthcare workers and people with high-risk of COVID-19 infection, particularly in low-to-middle income countries.[48][49]


As of December 2020, US$2.4 billion had been raised for the overall ACT Accelerator, with nine vaccine candidates being funded by COVAX and CEPI – the world's largest COVID-19 vaccine portfolio – with 189 countries committed to the eventual deployment plan.[50][51] Earlier in 2020, the WHO had a telethon which raised US$8.8 billion in pledges from forty countries to support rapid development of vaccines.[52]


In July, the WHO announced that 165 countries, representing up to 60% of the world population, had agreed to a WHO COVAX plan for fair and equitable distribution of an eventual licensed vaccine, assuring that each participating country would receive a guaranteed share of doses to vaccinate the most vulnerable 20% of its population by the end of 2021.[53]


The Global Research Collaboration for Infectious Disease Preparedness (GLoPID-R) is working closely with the WHO and member states to identify priorities for funding specific research needed for a COVID‑19 vaccine, coordinating among the international funding and research organizations to maintain updated information on vaccine progress and avoid duplicate funding.[54][55] The International Severe Acute Respiratory and Emerging Infection Consortium is organizing and disseminating clinical information on COVID‑19 research to inform public health policy on eventual vaccine distribution.[56]


On 4 June, a virtual summit was coordinated from London, UK, among private and government representatives of 52 countries, including 35 heads of state from G7 and G20 nations, to raise US$8.8 billion in support of the Global Alliance for Vaccines and Immunisation (GAVI) to prepare for COVID‑19 vaccinations of 300 million children in under-developed countries through 2025.[57] Major contributions were US$1.6 billion from The Gates Foundation[58] and GB£330 million per year over five years by the British government (approximately US$2.1 billion in June 2020).[57]


In December, the Gates Foundation donated another US$250 million to the WHO ACT Accelerator to "support the delivery of new COVID-19 tests, treatments, and vaccines, particularly in low- and middle-income countries" during 2021, making the Foundation's total donation of US$1.75 billion toward the COVID-19 response.[59][60]


Coalition for Epidemic Preparedness Innovations

A multinational organization formed in 2017, CEPI is working with international health authorities and vaccine developers to create vaccines for preventing epidemics.[49] CEPI has organized a US$2 billion fund in a global partnership between public, private, philanthropic, and civil society organizations for accelerated research and clinical testing of nine COVID-19 vaccine candidates, with the 2020–21 goal of supporting several candidate vaccines for full development to licensing.[44][42][50] The United Kingdom, Canada, Belgium, Norway, Switzerland, Germany and the Netherlands had already donated US$915 million to CEPI by early May.[52][61] The Gates Foundation, a private charitable organization dedicated to vaccine research and distribution, is donating US$250 million in support of CEPI for research and public educational support on COVID‑19 vaccines.[62][63]


Over 2020 throughout the pandemic, CEPI was funding the development of nine vaccine candidates in a portfolio deliberately made diverse across different vaccine technologies to minimize the typically high risk of failure inherent in vaccine development.[50][64] As of December, the vaccine research organizations and programs being supported by CEPI were Clover Biopharmaceuticals (vaccine candidate, SCB-2019), CureVac, Inovio, Institut Pasteur (vaccine candidate, MV-SARS-CoV-2), Moderna, Novavax, AZD1222 (University of Oxford-AstraZeneca), Hong Kong University, and SK bioscience (vaccine candidate, GBP510).[50][65][66]


National governments

National governments dedicating resources for national or international investments in vaccine research, development, and manufacturing beginning in 2020, included the Canadian government which announced CA$275 million in funding for 96 research vaccine research projects at Canadian companies and universities, with plans to establish a "vaccine bank" of several new vaccines that could be used if another coronavirus outbreak occurs.[67][68] A further investment of CA$1.1 billion was added to support clinical trials in Canada and develop manufacturing and supply chains for vaccines.[55] On 4 May, the Canadian government committed CA$850 million to the WHO's live streaming effort to raise US$8 billion for COVID‑19 vaccines and preparedness.[69]


In China, the government is providing low-rate loans to a vaccine developer through its central bank, and has "quickly made land available for the company" to build production plants.[61] As of June 2020, six of the eleven COVID‑19 vaccine candidates in early-stage human testing were developed by Chinese organizations.[62] Three Chinese vaccine companies and research institutes are supported by the government for financing research, conducting clinical trials, and manufacturing the most promising vaccine candidates, while prioritizing rapid evidence of efficacy over safety.[70] On 18 May, China had pledged US$2 billion to support overall efforts by the WHO for programs against COVID‑19.[71] On 22 July, China additionally announced that it plans to provide a US$1 billion loan to make its vaccine accessible for countries in Latin America and the Caribbean.[72] On 24 August, Chinese Premier Li Keqiang announced it would provide five Southeast Asian countries of Cambodia, Laos, Myanmar, Thailand and Vietnam priority access to the vaccine once it was fully developed.[73]


Among European Union countries, France announced a US$4.9 million investment in a COVID‑19 vaccine research consortium via CEPI involving the Institut Pasteur, Themis Bioscience (Vienna, Austria), and the University of Pittsburgh, bringing CEPI's total investment in COVID‑19 vaccine development to US$480 million by May.[74][75] In March, the European Commission made an €80 million investment in CureVac, a German biotechnology company, to develop a mRNA vaccine.[76] The German government announced a separate €300 million investment in CureVac in June.[77] Belgium, Norway, Switzerland, Germany, and the Netherlands have been major contributors to the CEPI effort for COVID‑19 vaccine research in Europe.[61]


In April, the British government formed a COVID‑19 vaccine task force to stimulate British efforts for rapidly developing a vaccine through collaborations of industry, universities, and government agencies across the vaccine development pipeline, including clinical trial placement at British hospitals, regulations for approval, and eventual manufacturing.[78] The vaccine development initiatives at the University of Oxford and Imperial College of London were financed with GB£44 million in April.[79][80]



US Government Accountability Office diagram comparing a traditional vaccine development timeline to a possible expedited timeline

The United States Biomedical Advanced Research and Development Authority (BARDA), a federal agency that funds disease-fighting technology, announced investments of nearly US$1 billion to support American COVID‑19 vaccine development, and preparation for manufacturing the most promising candidates. On 16 April, BARDA made a US$483 million investment in the vaccine developer, Moderna and its partner, Johnson & Johnson.[61][81] BARDA has an additional US$4 billion to spend on vaccine development, and will have roles in other American investment for development of six to eight vaccine candidates to be in clinical studies over 2020–21 by companies such as Sanofi Pasteur and Regeneron.[81][82] On 15 May, the US government announced federal funding for a fast-track program called Operation Warp Speed, which has the goals of placing diverse vaccine candidates in clinical trials by the fall of 2020, and manufacturing 300 million doses of a licensed vaccine by January 2021. The project chief advisor is Moncef Slaoui and its chief operating officer is Army General Gustave Perna.[83][84] In June, the Warp Speed team said it would work with seven companies developing COVID‑19 vaccine candidates: Moderna, Johnson & Johnson, Merck, Pfizer, and the University of Oxford in collaboration with AstraZeneca, as well as two others,[85] although Pfizer later stated that "all the investment for R&D was made by Pfizer at risk."[86]


WHO COVID-19 trials

In April 2020, the WHO published an "R&D Blueprint (for the) novel Coronavirus" (Blueprint). The Blueprint documented a "large, international, multi-site, individually randomized controlled clinical trial" to allow "the concurrent evaluation of the benefits and risks of each promising candidate vaccine within 3–6 months of it being made available for the trial." The Blueprint listed a Global Target Product Profile (TPP) for COVID‑19, identifying favorable attributes of safe and effective vaccines under two broad categories: "vaccines for the long-term protection of people at higher risk of COVID‑19, such as healthcare workers", and other vaccines to provide rapid-response immunity for new outbreaks.[41] The international TPP team was formed to 1) assess the development of the most promising candidate vaccines; 2) map candidate vaccines and their clinical trial worldwide, publishing a frequently-updated "landscape" of vaccines in development;[87] 3) rapidly evaluate and screen for the most promising candidate vaccines simultaneously before they are tested in humans; and 4) design and coordinate a multiple-site, international randomized controlled trial – the "Solidarity trial" for vaccines[41][88] – to enable simultaneous evaluation of the benefits and risks of different vaccine candidates under clinical trials in countries where there are high rates of COVID‑19 disease, ensuring fast interpretation and sharing of results around the world.[41] The WHO vaccine coalition will prioritize which vaccines should go into Phase II and III clinical trials, and determine harmonized Phase III protocols for all vaccines achieving the pivotal trial stage.[41]


Adaptive design for the Solidarity trial

A clinical trial design in progress may be modified as an "adaptive design" if accumulating data in the trial provide early insights about positive or negative efficacy of the treatment.[89][90] The WHO Solidarity trial of multiple vaccines in clinical studies during 2020, will apply adaptive design to rapidly alter trial parameters across all study sites as results emerge.[88] Candidate vaccines may be added to the Solidarity trial as they become available if priority criteria are met, while vaccine candidates showing poor evidence of safety or efficacy compared to placebo or other vaccines will be dropped from the international trial.[88]


Adaptive designs within ongoing Phase II–III clinical trials on candidate vaccines may shorten trial durations and use fewer subjects, possibly expediting decisions for early termination or success, avoiding duplication of research efforts, and enhancing coordination of design changes for the Solidarity trial across its international locations.[88][89]


Partnerships, competition, and distribution

Large pharmaceutical companies with experience in making vaccines at scale, including Johnson & Johnson, AstraZeneca, and GlaxoSmithKline (GSK), are forming alliances with biotechnology companies, national governments, and universities to accelerate progression to an effective vaccine.[61][62] To combine financial and manufacturing capabilities for a pandemic adjuvanted vaccine technology, GSK joined with Sanofi in an uncommon partnership of multinational companies to support accelerated vaccine development.[91]


During a pandemic on the rapid timeline and scale of COVID‑19 infections during 2020, international organizations like the WHO and CEPI, vaccine developers, governments, and industry are evaluating distribution of the eventual vaccine(s).[41] Individual countries producing a vaccine may be persuaded to favor the highest bidder for manufacturing or provide first-service to their own country.[35][38][61] Experts emphasize that licensed vaccines should be available and affordable for people at the frontline of healthcare and having the greatest need.[35][38][61] Under their agreement with AstraZeneca, the University of Oxford vaccine development team and British government agreed that British citizens would not get preferential access to a new COVID‑19 vaccine developed by the taxpayer-funded university, but rather consented to having a licensed vaccine distributed multinationally in cooperation with the WHO.[79] Several companies plan to initially manufacture a vaccine at low cost, then increase costs for profitability later if annual vaccinations are needed and as countries build stock for future needs.[61]


The WHO and CEPI are developing financial resources and guidelines for global deployment of several safe, effective COVID‑19 vaccines, recognizing the need is different across countries and population segments.[44][41][42][88] For example, successful COVID‑19 vaccines would likely be allocated first to healthcare personnel and populations at greatest risk of severe illness and death from COVID‑19 infection, such as the elderly or densely-populated impoverished people.[92][93] The WHO, CEPI, and GAVI have expressed concerns that affluent countries should not receive priority access to the global supply of eventual COVID‑19 vaccines, but rather protecting healthcare personnel and people at high risk of infection are needed to address public health concerns and reduce economic impact of the pandemic.[37][42][92]


Compressed timelines

Geopolitical issues, safety concerns for vulnerable populations, and manufacturing challenges for producing billions of doses are compressing schedules to shorten the standard vaccine development timeline, in some cases combining clinical trial steps over months, a process typically conducted sequentially over years.[62] As an example, Chinese vaccine developers and the government Chinese Center for Disease Control and Prevention began their efforts in January 2020,[94] and by March were pursuing numerous candidates on short timelines, with the goal to showcase Chinese technology strengths over those of the United States, and to reassure the Chinese people about the quality of vaccines produced in China.[62][95]


In the haste to provide a vaccine on a rapid timeline for the COVID‑19 pandemic, developers and governments are accepting a high risk of "short-circuiting" the vaccine development process,[61] with one industry executive saying: "The crisis in the world is so big that each of us will have to take maximum risk now to put this disease to a stop".[61] Multiple steps along the entire development path are evaluated, including the level of acceptable toxicity of the vaccine (its safety), targeting vulnerable populations, the need for vaccine efficacy breakthroughs, the duration of vaccination protection, special delivery systems (such as oral or nasal, rather than by injection), dose regimen, stability and storage characteristics, emergency use authorization before formal licensing, optimal manufacturing for scaling to billions of doses, and dissemination of the licensed vaccine.[35][96] From Phase I clinical trials, 84–90%[37][97] of vaccine candidates fail to make it to final approval during development, and from Phase III, 25.7% fail[97] – the investment by a manufacturer in a vaccine candidate may exceed US$1 billion and end with millions of useless doses.[35][61][62] In the case of COVID‑19 specifically, a vaccine efficacy of 70% may be enough to stop the pandemic, but if it has only 60% efficacy, outbreaks may continue; an efficacy of less than 60% will not provide enough herd immunity to stop the spread of the virus alone.[35]


As the pandemic expands during 2020, research at universities is obstructed by physical distancing and closing of laboratories.[98][99] Globally, supplies critical to vaccine research and development are increasingly scarce due to international competition or national sequestration.[70] Timelines for conducting clinical research – normally a sequential process requiring years – are being compressed into safety, efficacy, and dosing trials running simultaneously over months, potentially compromising safety assurance.[61][62]


Technology platforms

CEPI scientists reported in September 2020 that nine different technology platforms – with the technology of numerous candidates remaining undefined – were under research and development during 2020 to create an effective vaccine against COVID‑19.[44] According to CEPI, most of the platforms of vaccine candidates in clinical trials are focused on the coronavirus spike protein and its variants as the primary antigen of COVID‑19 infection.[44] Platforms being developed in 2020 involved nucleic acid technologies (nucleoside-modified messenger RNA and DNA), non-replicating viral vectors, peptides, recombinant proteins, live attenuated viruses, and inactivated viruses.[35][37][44][100]


Many vaccine technologies being developed for COVID‑19 are not like vaccines already in use to prevent influenza, but rather are using "next-generation" strategies for precision on COVID‑19 infection mechanisms.[37][44][100] Vaccine platforms in development may improve flexibility for antigen manipulation and effectiveness for targeting mechanisms of COVID‑19 infection in susceptible population subgroups, such as healthcare workers, the elderly, children, pregnant women, and people with existing weakened immune systems.[37][44]



Potential candidates for forming SARS-CoV-2 proteins to prompt an immune response

COVID‑19 vaccine technology platforms, December 2020[101]

Molecular platform[i] Total number

of candidates Number of candidates

in human trials

Inactivated virus

19

5[ii]

Non-replicating viral vector

35

4[ii]

RNA-based

36

3[ii]

Protein subunit

80

2[ii]

DNA-based

23

2[ii]

Virus-like particle

19

1[ii]

Replicating viral vector

23

0

Live attenuated virus

4

0

 Technologies for dozens of candidates are unannounced or "unknown".[101]

 One or more candidates in Phase II or Phase II–III trials.

Vaccines

CEPI classifies development stages for vaccines as "exploratory" (planning and designing a candidate, having no evaluation in vivo), "preclinical" (in vivo evaluation with preparation for manufacturing a compound to test in humans), or initiation of Phase I safety studies in healthy people.[44] Some 321 total vaccine candidates were in development as either confirmed projects in clinical trials or in early-stage "exploratory" or "preclinical" development, as of September.[44]


Phase I trials test primarily for safety and preliminary dosing in a few dozen healthy subjects, while Phase II trials – following success in Phase I – evaluate immunogenicity, dose levels (efficacy based on biomarkers) and adverse effects of the candidate vaccine, typically in hundreds of people.[102][103] A Phase I–II trial consists of preliminary safety and immunogenicity testing, is typically randomized, placebo-controlled, while determining more precise, effective doses.[103] Phase III trials typically involve more participants at multiple sites, include a control group, and test effectiveness of the vaccine to prevent the disease (an "interventional" or "pivotal" trial), while monitoring for adverse effects at the optimal dose.[102][103] Definition of vaccine safety, efficacy, and clinical endpoints in a Phase III trial may vary between the trials of different companies, such as defining the degree of side effects, infection or amount of transmission, and whether the vaccine prevents moderate or severe COVID‑19 infection.[104][105][106]


Approved vaccines

Approved vaccines for emergency use or full authorization

Vaccine candidates,

developers, and sponsors Technology Current phase (participants)

design Completed phase[c] (participants)

Immune response EUA Full authorization

BBIBP-CorV[107]

Sinopharm: Beijing Institute of Biological Products, Wuhan Institute of Biological Products Inactivated SARS-CoV-2 (vero cells) Phase III (48,000)

Randomized, double-blind, parallel placebo-controlled, to evaluate safety and protective efficacy.

Positive results from an interim analysis were announced by the UAE on 9 December 2020 with an efficacy of 86%.[108][109]

Location(s): UAE, Bahrain, Jordan,[110] Argentina,[111] Morocco,[112] Peru[113]

Duration: Jul 2020 – Jul 2021


Phase I–II (320)

Neutralizing antibodies at day 14 after 2 injections[114]

Location(s): China

Duration: Apr 2020 – Jun 2020 Approved

China: NHC (Jul. 2020)[115]

Approved

UAE: MOH (9 December 2020)[116][117][118]

Bahrain: NHRA (13 December 2020)

CoronaVac[119][120][121]

Sinovac Inactivated SARS-CoV-2 Phase III (33,620)

Double-blind, randomized, placebo-controlled to evaluate efficacy and safety.

Location(s): Brazil (15,000);[122] Chile (3,000);[123] Indonesia (1,620); Turkey (13,000)[124]

Duration: Jul 2020 – Oct 2021 in Brazil; Aug 2020 – Jan 2021 in Indonesia Phase II (600)

Immunogenicity eliciting 92% seroconversion at lower dose and 98% at higher dose after 14 days[125]

Location(s): China

Duration: May 2020 - Approved

China: NHC (Jul. 2020)[126]

Pending

Turkey: Ministry of Health[127]

Gam-COVID-Vac (Sputnik V)

Gamaleya Research Institute of Epidemiology and Microbiology; trade name: Sputnik V Non-replicating viral vector (adenovirus) Phase III (40,000)

Randomized double-blind, placebo-controlled to evaluate efficacy, immunogenicity, and safety[128]

Location(s): Russia, India[129][130]

Duration: Aug 2020 - May 2021 Phase I–II (76)

Neutralizing antibody and T cell responses.[131]

Location(s): Russia

Duration: Jun 2020[131] - Sep 2020 Approved

Russia: Ministry of Health (11 August 2020)[132]

mRNA-1273[133][134]

Moderna, NIAID, BARDA Lipid nanoparticle dispersion containing modRNA Phase III (30,000)

Interventional; randomized, placebo-controlled study for efficacy, safety, and immunogenicity.

Positive results from an interim analysis were announced on 15 November 2020.[135]

Location(s): United States

Duration: Jul 2020 – Oct 2022


Phase I–II (720)[136][137]

Dose-dependent neutralizing antibody response on two-dose schedule; undetermined durability.[138][139][140]

Location(s): United States

Duration: Mar 2020 – Nov 2021 Approved

US: FDA (18 December 2020)[19]

Pending

EU: EMA[141]

UK: MHRA[142]

Canada[143]

Pending

Switzerland: Swissmedic[144][145]

Tozinameran[4][146][147]

BioNTech, Pfizer, Fosun Pharma modRNA Phase III (43,448)[148]

Positive results from an interim analysis were announced on 18 November 2020[149] and published on 10 December 2020 reporting an overall efficacy of 95%.[150][151]

Randomized, placebo-controlled

Location(s): Germany, United States

Duration: Jul 2020 – Nov 2020[152][153]


Phase I–II (45)

Strong RBD-binding IgG and neutralizing antibody response peaked 7 days after a booster dose, robust CD4+ and CD8+ T cell responses, undetermined durability[154][155]

Duration: May. 2020 – Approved

UK: MHRA (2 December 2020)[1][156][157]

Bahrain: NHRA[158]

Canada: Health Canada[4][143]

US: FDA (11 December 2020)[159][160][161][162]

Mexico: COFEPRIS[163]

Kuwait: MOH[164]

Singapore[165]

Jordan: JFDA[166]

Oman: MOH[11]

Costa Rica: DRFIS[13]

Ecuador: ARCSA[12]

Panama: MOH[14]

Chile: ISP[15]

Approved


Saudi Arabia: SFDA (10 December 2020)[167][168]

Switzerland: Swissmedic (19 December 2020)[16]

Vaccine candidates

COVID‑19 candidate vaccines in Phase I–III trials[101][169][87]

Vaccine candidates,

developers, and sponsors Technology Current phase (participants)

design Completed phase[d] (participants)

Immune response EUA Full authorization

AZD1222[e][f][173][174][175]

University of Oxford, AstraZeneca Modified chimpanzee adenovirus vector (ChAdOx1) Phase III (30,000)

Interventional; randomized, placebo-controlled study for efficacy, safety, and immunogenicity.[176]

Positive results from an interim analysis of four ongoing trials were announced on 23 November 2020 and published on 8 December 2020.[177] Overall efficacy was 70%, ranging from 62% to 90% with different dosing regimens, with a peer-reviewed safety profile.[177]

Location(s): Brazil (5,000)[178], United Kingdom, India[179]

Duration: May 2020 – Aug 2021


Phase I–II (543)

Spike-specific antibodies at day 28; neutralizing antibodies after a booster dose at day 56[180] Pending

India: DCGI[181]

Canada[143]

Mexico: COFEPRIS[182]

Pending

Switzerland: Swissmedic[183][145]

Ad5-nCoV

CanSino Biologics, Beijing Institute of Biotechnology of the Academy of Military Medical Sciences, NPO Petrovax[184][g] Recombinant adenovirus type 5 vector Phase III (40,000)

global multi-center, randomized, double-blind, placebo-controlled to evaluate efficacy, safety and immunogenicity.

Location(s): China, Argentina, Chile,[186] Mexico,[187] Pakistan,[188] Russia,[184] Saudi Arabia[189][190]

Duration: Mar. – Dec. 2020, China; Sep. 2020 – Dec. 2021, Pakistan; Sep. 2020 – Nov. 2020, Russia[184] Phase II (508)

Neutralizing antibody and T cell responses[191] Pending

Mexico: COFEPRIS[192]

Ad26.COV2.S[193][194][195]

Janssen Pharmaceutica (Johnson & Johnson), BIDMC


Non-replicating viral vector (adenovirus serotype 26) Phase III (40,000)

Randomized, double-blinded, placebo-controlled

Temporarily paused on 13 October 2020, due to an unexplained illness in a participant.[196] Johnson & Johnson announced, on 23 October, that they are preparing to resume the trial in the US.[197][198]

Location(s): United Staes, Argentina, Brazil, Chile, Colombia, Mexico, Peru, Philippines, South Africa and Ukraine

Duration: Jul 2020 – 2023


Phase I–II (1,045) Preprint. Seroconversion for S antibodies over 95%. Pending

Canada[143]

EU: EMA[199]

South Africa[200]

NVX-CoV2373[201]

Novavax SARS-CoV-2 recombinant spike protein nanoparticle with adjuvant Phase III (15,000)

Randomised, observer-blinded, placebo-controlled trial[202]

Location(s): UK, India[203]

Duration: Sep 2020 – Jan 2021 Phase I–II (131) IgG and neutralizing antibody response with adjuvant after booster dose[204] Pending

Mexico: COFEPRIS[205]

BBV152 (Covaxin)

Bharat Biotech, Indian Council of Medical Research


Inactivated SARS-CoV-2 Phase III (25,800)

Randomised, observer-blinded, placebo-controlled[206]

Location(s): India

Duration: Nov 2020 – Mar 2022 Phase I (375) Dose-dependent neutralizing antibody response on two-dose schedule.

[207]

Pending Phase II reports[208]


Pending

India: DCGI[209]

CoVLP[210]

Medicago, GSK


Recombinant, plant-based virus-like particles[h] with GSK adjuvant Phase II–III (30,612)

Event-driven, randomized, observer blinded, placebo-controlled[212]

Location(s): Canada

Duration: Nov 2020 – Apr 2022 Phase I (180)

Neutralizing antibodies at day 42 after the first injection (day 21 after the second injection) were at levels 10x that of COVID-19 survivors.[213][214]

Unnamed[101][169][87][215]

Anhui Zhifei Longcom Biopharmaceutical Co. Ltd. Recombinant subunit vaccine Phase II (900)

Interventional; randomized, double-blind, placebo-controlled[216]

Location(s): Chongqing

Duration: Jun 2020 – Sep 2021 Phase I (50)

Zorecimeran (CVnCoV)

CureVac, CEPI modRNA Phase III (36,500)[217]

Phase 2b/3: Multicenter efficacy and safety trial in adults

Location(s): Argentina, Belgium, Colombia, Dominican Republic, France, Germany, Mexico, Netherlands, Panama, Peru, Spain

Duration: Nov 2020 – ? Phase I–II (944)[218][219]

Phase 1 (284): Partially blind, controlled, dose-escalation to evaluate safety, reactogenicity and immunogenicity.

Phase 2a (660):Partially observer-blind, multicenter, controlled, dose-confirmation.

Location(s): Belgium (P1), Germany (P1), Panama (2a), Peru (2a)

Duration: Jun 2020 – Oct 2021


INO-4800[i][220][221]

Inovio, CEPI, Korea National Institute of Health, International Vaccine Institute DNA plasmid delivered by electroporation Phase I–II (40)

Location(s): United States, South Korea

Duration: Apr–Nov 2020 Pending Phase I report

EpiVacCorona[222]

Vector Vaccine based on peptide antigens[222] Phase I–II (100)

Simple, blind, placebo-controlled, randomized study of safety, reactogenicity and immunogenicity[222]

Location(s): Russia

Duration: Jul 2020[222] – ? Pending Phase I–II report

Unnamed[223]

Chinese Academy of Medical Sciences Inactivated SARS-CoV-2 Phase I–II (942)

Randomized, double-blinded, single-center, placebo-controlled

Location(s): Chengdu

Duration: Jun 2020 – Sep 2021

AG0301-COVID‑19[224]

AnGes Inc.,[225] AMED DNA plasmid Phase I–II (30)

Non-randomized, single-center, two doses

Location(s): Osaka

Duration: Jun 2020 – Jul 2021

Lunar-COV19/ARCT-021[226][227]

Arcturus Therapeutics


mRNA Phase I–II (92)

Randomized, double-blinded

Location(s): Singapore

Duration: Aug 2020 – ?

COVID‑19/aAPC[228]

Shenzhen Genoimmune Medical Institute[229] Lentiviral vector with minigene modifying aAPCs Phase I (100)

Location(s): Shenzhen

Duration: Mar 2020 – 2023

LV-SMENP-DC[230]

Shenzhen Genoimmune Medical Institute[229] Lentiviral vector with minigene modifying DCs Phase I (100)

Location(s): Shenzhen

Duration: Mar 2020 – 2023

LNP-nCoVsaRNA[231]

MRC clinical trials unit at Imperial College London mRNA Phase I (105)

Randomized trial, with dose escalation study (15) and expanded safety study (at least 200)

Location(s): United Kingdom

Duration: Jun 2020 – Jul 2021

ZyCoV-D[232]

Cadila Healthcare


DNA plasmid expressing SARS-CoV-2 S protein Phase I–II (1,000)

Interventional; randomized, double-blind, placebo-controlled[233][234]

Location(s): India

Duration: Jul 2020 – Apr 2021

GX-19[235][236]

Genexine consortium,[237] International Vaccine Institute DNA Phase I (40)

Location(s): Seoul

Duration: Jun 2020 – Jun 2022

SCB-2019[238][239]

Clover Biopharmaceuticals,[240] GSK Spike protein trimeric subunit with GSK adjuvant Phase I (150)

Location(s): Perth

Duration: Jun 2020 – Mar 2021

COVAX-19[241]

Vaxine Pty Ltd[242] Recombinant protein Phase I (40)

Location(s): Adelaide

Duration: Jun 2020 – Jul 2021

Unnamed[243]

PLA Academy of Military Science, Walvax Biotech[244] mRNA Phase I (168)

Location(s): China

Duration: Jun 2020 – Dec 2021

SARS-CoV-2 Sclamp/V451[245][246]

UQ, Syneos Health, CEPI, Seqirus Molecular clamp stabilized spike protein with MF59 Phase I (120)

Randomised, double-blind, placebo-controlled, dose-ranging

Location(s): Brisbane

Duration: Jul–Oct 2020 N/A N/A

Testing and development terminated in December 2020 due to false positive HIV test found among participants

 Switzerland does not have an EUA procedure, but some vaccines have general or conditional use approval applications.

 The United Kingdom,[1] Bahrain,[2] United Arab Emirates,[3] Canada,[4] Saudi Arabia,[5] the United States,[6] Mexico,[7] Kuwait,[8] Singapore,[9] Jordan,[10] Oman,[11] Ecuador,[12] Costa Rica,[13] Panama,[14] Chile,[15] and Switzerland.[16]

 Latest Phase with published results.

 Latest Phase with published results.

 Serum Institute of India will be producing the ChAdOx1 nCoV-19 vaccine for India[170] and other low and middle income countries.[171]

 Oxford name: ChAdOx1 nCoV-19. Manufacturing in Brazil to be carried out by Oswaldo Cruz Foundation.[172]

 Manufacturing partnership with the National Research Council of Canada and Canadian Center for Vaccinology, Halifax, Nova Scotia[185]

 Virus-like particles grown in Nicotiana benthamiana[211]

 South Korean Phase I–II in parallel with Phase I in the US

Preclinical research

In April 2020, the WHO issued a statement representing dozens of vaccine scientists around the world, pledging collaboration to speed development of a vaccine against COVID‑19.[247] The WHO coalition is encouraging international cooperation between organizations developing vaccine candidates, national regulatory and policy agencies, financial contributors, public health associations, and governments, for eventual manufacturing of a successful vaccine in quantities sufficient to supply all affected regions, particularly low-resource countries.[37]


Industry analysis of past vaccine development shows failure rates of 84–90%.[37][97] Because COVID‑19 is a novel virus target with properties still being discovered and requiring innovative vaccine technologies and development strategies, the risks associated with developing a successful vaccine across all steps of preclinical and clinical research are high.[37]


To assess potential for vaccine efficacy, unprecedented computer simulations and new COVID‑19-specific animal models are being developed multinationally during 2020, but these methods remain untested by unknown characteristics of the COVID‑19 virus.[37] Of the confirmed active vaccine candidates, about 70% are being developed by private companies, with the remaining projects under development by academic, government coalitions, and health organizations.[44]


Most of the vaccine developers are small firms or university research teams with little experience in successful vaccine design and limited capacity for advanced clinical trial costs and manufacturing without partnership by multinational pharmaceutical companies.[44][37]


Scheduled Phase I trials in 2020

Many vaccine candidates under design or preclinical development for COVID‑19 will not gain approval for human studies in 2020, due to toxicity, ineffectiveness to induce immune responses or dosing failures in laboratory animals, or because of underfunding.[248][249] The probability of success for an infectious disease vaccine candidate to pass preclinical barriers and reach Phase I of human testing is 41–57%.[248]


Commitment to first-in-human testing of a vaccine candidate represents a substantial capital cost for vaccine developers, estimated to be from US$14 million to US$25 million for a typical Phase I trial program, but possibly as much as US$70 million.[248][250] For comparison, during the Ebola virus epidemic of 2013–16, there were 37 vaccine candidates in urgent development, but only one eventually succeeded as a licensed vaccine, involving a total cost to confirm efficacy in Phase II–III trials of about US$1 billion.[248]


BCG vaccine

There is experimental evidence that the BCG vaccine has non-specific effects on the immune system, but no evidence that this vaccine is effective against COVID‑19.[251][252]


Use of adjuvants

In September 2020, eleven of the vaccine candidates in clinical development used adjuvants to enhance immunogenicity.[44] An immunological adjuvant is a substance formulated with a vaccine to elevate the immune response to an antigen, such as the COVID‑19 virus or influenza virus.[253] Specifically, an adjuvant may be used in formulating a COVID‑19 vaccine candidate to boost its immunogenicity and efficacy to reduce or prevent COVID-19 infection in vaccinated individuals.[253][254] Adjuvants used in COVID‑19 vaccine formulation may be particularly effective for technologies using the inactivated COVID-19 virus and recombinant protein-based or vector-based vaccines.[254] Aluminum salts, known as "alum", were the first adjuvant used for licensed vaccines, and are the adjuvant of choice in some 80% of adjuvanted vaccines.[254] The alum adjuvant initiates diverse molecular and cellular mechanisms to enhance immunogenicity, including release of proinflammatory cytokines.[253][254]


Potential limitations

The rapid development and urgency of producing a vaccine for the COVID‑19 pandemic may increase the risks and failure rate of delivering a safe, effective vaccine.[100][37][255] One study found that between 2006 and 2015, the success rate of obtaining approval from Phase I to successful Phase III trials was 16.2% for vaccines,[97] and CEPI indicates a potential success rate of only 10% for vaccine candidates in 2020 development.[37]


An April 2020 CEPI report stated: "Strong international coordination and cooperation between vaccine developers, regulators, policymakers, funders, public health bodies and governments will be needed to ensure that promising late-stage vaccine candidates can be manufactured in sufficient quantities and equitably supplied to all affected areas, particularly low-resource regions."[37]


Biosafety concern

Early research to assess vaccine efficacy using COVID‑19-specific animal models, such as ACE2-transgenic mice, other laboratory animals, and non-human primates, indicates a need for biosafety-level 3 containment measures for handling live viruses, and international coordination to ensure standardized safety procedures.[100][37]


Antibody-dependent enhancement

Main article: Antibody-dependent enhancement

Although the quality and quantity of antibody production by a potential vaccine is intended to neutralize the COVID‑19 infection, a vaccine may have an unintended opposite effect by causing antibody-dependent disease enhancement (ADE), which increases the virus attachment to its target cells and might trigger a cytokine storm if a vaccinated person is later attacked by the virus.[100][256] The vaccine technology platform (for example, viral vector vaccine, spike (S) protein vaccine or protein subunit vaccine), vaccine dose, timing of repeat vaccinations for the possible recurrence of COVID‑19 infection, and elderly age are factors determining the risk and extent of ADE.[100][256] The antibody response to a vaccine is a variable of vaccine technologies in development, including whether the vaccine has precision in its mechanism,[100] and choice of the route for how it is given (intramuscular, intradermal, oral, or nasal).[256][257]


Efficacy

See also: Vaccine efficacy

The effectiveness of new vaccine is defined by its efficacy.[153] An efficacy of less than 60% may result in failure to create herd immunity.[35][257] Host-("vaccinee")-related determinants that render a person susceptible to infection, such as genetics, health status (underlying disease, nutrition, pregnancy, sensitivities or allergies), immune competence, age, and economic impact or cultural environment can be primary or secondary factors affecting the severity of infection and response to a vaccine.[257] Elderly (above age 60), allergen-hypersensitive, and obese people have susceptibility to compromised immunogenicity, which prevents or inhibits vaccine effectiveness, possibly requiring separate vaccine technologies for these specific populations or repetitive booster vaccinations to limit virus transmission.[257] Further, mutations of the virus can alter its structure targeted by the vaccine, thus making the vaccine ineffective.[258][259] As example of the latter, the mutated version of the virus in the Cluster 5 outbreak, affecting minks in Denmark, is unlikely to respond to vaccines currently under development, according to investigators Kåre Mølbak and Tyra Grove Krause.[260]


Enrollment of participants in trials

Vaccine developers have to invest resources internationally to find enough participants for Phase II–III clinical trials when the virus has proved to be a "moving target" of changing transmission rate across and within countries, forcing companies to compete for trial participants.[104] As an example in June, the Chinese vaccine developer Sinovac formed alliances in Malaysia, Canada, the UK, and Brazil among its plans to recruit trial participants and manufacture enough vaccine doses for a possible Phase III study in Brazil where COVID‑19 transmission was accelerating during June.[104] As the COVID‑19 pandemic within China became more isolated and controlled, Chinese vaccine developers sought international relationships to conduct advanced human studies in several countries, creating competition for trial participants with other manufacturers and the international Solidarity trial organized by the WHO.[104] In addition to competition over recruiting participants, clinical trial organizers may encounter people unwilling to be vaccinated due to vaccine hesitancy[261] or disbelieving the science of the vaccine technology and its ability to prevent infection.[262]


Having an insufficient number of skilled team members to administer vaccinations may hinder clinical trials that must overcome risks for trial failure, such as recruiting participants in rural or low-density geographic regions, and variations of age, race, ethnicity, or underlying medical conditions.[104][263]


Vaccine hesitancy

Some 10% of the public perceives vaccines as unsafe or unnecessary, refusing vaccination – a global health threat called vaccine hesitancy[264] – which increases the risk of further viral spread that could lead to COVID‑19 outbreaks.[261] In mid-2020, estimates from two surveys were that 67% or 80% of people in the U.S. would accept a new vaccination against COVID‑19, with wide disparity by education level, employment status, race, and geography.[265][266]


A poll conducted by National Geographic and Morning Consult demonstrated a gender gap on willingness to take a COVID-19 vaccine in the U.S., with 69% of men polled saying they would take the vaccine, compared to only 51% of women. The poll also showed a positive correlation between education level and willingness to take the vaccine.[267]


Cost

An effective vaccine for COVID‑19 could save trillions of dollars in global economic impact, according to one expert, and would, therefore, make any price tag in the billions look small in comparison.[268] In early stages of the pandemic, it was not known if it would be possible to create a safe, reliable and affordable vaccine for this virus, and it was not known exactly how much the vaccine development could cost.[35][38][62] There was a possibility that billions of dollars could be invested without success.[61]


Once an effective vaccine would be developed, billions of doses would need to be manufactured and distributed worldwide. In April 2020, the Gates Foundation estimated that manufacturing and distribution could cost as much as US$25 billion.[269] On 4 May 2020, the European Commission organized and held a video conference of world leaders, at which US$8 billion was raised for COVID‑19 vaccine development.[270]


As of November 2020, companies subsidized under the United States' Operation Warp Speed program have set initial pricing at US$19.50 to US$25 per dose, in line with the influenza vaccine.[271] In December 2020, a Belgian politician briefly published the confidential prices agreed between vaccine producers and the EU:[272]


Manufacturer EU price per dose[273]

AstraZeneca €1.78

Johnson&Johnson US$8.50

Sanofi/GSK €7.56

Pfizer/BioNTech €12.00

Curevac €10.00

Moderna US$18.00

Rollout

See also: COVID-19 vaccination programme in the United Kingdom

Different vaccines have different shipping and handling requirements. For example, the Pfizer/BioNTech vaccine tozinameran (Pfizer-BioNTech COVID-19 Vaccine) must be shipped and stored between −80 and −60 °C (−112 and −76 °F),[274] must be used within five days of thawing,[274] and has a minimum order of 975 doses, making it unlikely to be rolled out in settings other than large, well-equipped hospitals.[275]. Due to the December 2020 nor'easter, distributing the vaccine became more complicated across the Northeastern United States. [276]


Proposed challenge studies

Main article: Human challenge study

Strategies are being considered for fast-tracking the licensing of a vaccine against COVID‑19, especially by compressing (to a few months) the usually lengthy duration of Phase II–III trials (typically many years).[277][278][279] Challenge studies have been implemented previously for diseases less deadly than COVID‑19 infection, such as common influenza, typhoid fever, cholera, and malaria.[278][280] Following preliminary proof of safety and efficacy of a candidate vaccine in laboratory animals and healthy humans, controlled challenge studies might be implemented to bypass typical Phase III research, providing an accelerated path to license a COVID‑19 vaccine.[277][280][278] Beginning in January 2021, dozens of young adult volunteers will be deliberately infected with COVID‑19 in a challenge trial conducted in a London hospital under management by the British government COVID-19 Vaccine Taskforce.[281] Once an infection dose of COVID‑19 is identified, two or more of the candidate COVID-19 vaccines will be tested for effectiveness in preventing infection.[281]


A challenge study begins by simultaneously testing a vaccine candidate for immunogenicity and safety in laboratory animals and healthy adult volunteers (100 or fewer), something normally a sequential process using animals first.[277][278] If the initial tests are promising, the study proceeds by rapidly advancing the effective dose into a large-scale Phase II–III trial in previously-uninfected, low-risk volunteers (such as young adults), who would then be deliberately infected with COVID‑19 for comparison with a placebo control group.[277][278][280] Following the challenge, the volunteers would be monitored closely in clinics with life-saving resources, if needed.[277][278] Volunteering for a vaccine challenge study during the COVID‑19 pandemic is likened to the emergency service of healthcare personnel for COVID‑19-infected people, firefighters, or organ donors.[277]


Although challenge studies are ethically questionable due to the unknown hazards for the volunteers of possible COVID‑19 disease enhancement and whether the vaccine received has long-term safety (among other cautions), challenge studies may be the only option to rapidly produce an effective vaccine that will minimize the projected millions of deaths worldwide from COVID‑19 infection,[277][282] according to some infectious disease experts.[277][278][280] The World Health Organization has developed a guidance document with criteria for conducting COVID‑19 challenge studies in healthy people, including scientific and ethical evaluation, public consultation and coordination, selection and informed consent of the participants, and monitoring by independent experts.[283]


Authorizations

At the beginning of the COVID‑19 pandemic in early 2020, the WHO issued a guideline as an Emergency Use Listing of new vaccines, a process derived from the 2013–16 Ebola epidemic.[284] It required that a vaccine candidate developed for a life-threatening emergency be manufactured using GMP and that it complete development according to WHO prequalification procedures.[284]


Even as new vaccines are developed during the COVID‑19 pandemic, licensure of COVID-19 vaccine candidates requires submission of a full dossier of information on development and manufacturing quality. In the EU, companies may use a "rolling review process", supplying data as they become available during Phase III trials, rather than developing the full documentation over months or years at the end of clinical research, as is typical. This rolling process allows the European Committee for Medicinal Products for Human Use to evaluate clinical data in real time, enabling a promising vaccine candidate to be approved on a rapid timeline by the European Medicines Agency (EMA).[285] A rolling review process for the Moderna vaccine candidate was initiated in October by Health Canada and the EMA,[286] and in November in Canada for the Pfizer-BioNTech candidate.[287]


On 24 June 2020, China approved the CanSino vaccine for limited use in the military and two inactivated virus vaccines for emergency use in high-risk occupations.[288] On 11 August 2020, Russia announced the approval of its Sputnik V vaccine for emergency use, though one month later only small amounts of the vaccine had been distributed for use outside of the phase 3 trial.[289] In September, the United Arab Emirates approved emergency use of Sinopharm's vaccine for healthcare workers,[290] followed by similar emergency use approval from Bahrain in November.[291]


In the United States, an emergency use authorization (EUA) is "a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic."[292] Once an EUA is issued by the FDA, the vaccine developer is expected to continue the Phase III clinical trial to finalize safety and efficacy data, leading to application for licensure (approval) in the United States.[292] In mid-2020, concerns that the FDA might grant a vaccine EUA before full evidence from a Phase III clinical trial was available raised broad concerns about the potential for lowered standards in the face of political pressure.[265][293][294] On 8 September 2020, nine leading pharmaceutical companies involved in COVID‑19 vaccine research signed a letter, pledging that they would submit their vaccines for emergency use authorization only after Phase III trials had demonstrated safety and efficacy.[295]


The Pfizer-BioNTech partnership submitted an EUA request to the FDA for Tozinameran (mRNA Vaccine BNT162b2) on 20 November 2020.[296][297] On 2 December 2020, the United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) gave temporary regulatory approval for the Pfizer–BioNTech vaccine,[298][299] becoming the first country to approve this vaccine and the first country in the Western world to approve the use of any COVID-19 vaccine.[1][300][301] On 8 December 2020, 90-year-old Margaret Keenan received the vaccine at University Hospital Coventry, becoming the first person known to be vaccinated outside of a trial,[302] as the UK's vaccination programme began.[303] However, other vaccines had been given earlier in Russia.[304] On 11 December 2020, the US Food and Drug Administration (FDA) granted an emergency use authorization (EUA) for the Pfizer-BioNTech vaccine.[18][305] The vaccine has subsequently been approved for use by a number of national health authorities.


Moderna submitted a request for an EUA to the FDA on 30 November 2020 for MRNA-1273.[306][307] On 18 December 2020, the FDA granted an EUA for the Moderna vaccine.[19][20]


Equitable access

During 2020 as the COVID-19 pandemic escalated globally and vaccine development intensified, the WHO COVAX Facility adopted the phrase, "No one is safe unless everyone is safe", to emphasize the need for equitable distribution of COVID-19 vaccines authorized for marketing.[308] Yet, by mid-December, some 16 countries representing only 14% of the world's population had preordered more than 10 billion vaccine doses or about 51% of the available world supply.[21][22] Specifically, Canada, Australia, and Japan – having only 1% of the world's COVID-19 cases – had collectively reserved some one billion vaccine doses,[22] while the COVAX Facility, with a goal to supply vaccines to nearly 100 low-to-middle income countries that cannot fully afford to pay for COVID-19 vaccines, had reserved only a few hundred million doses.[308] Preorders from rich countries were made during 2020 with 13 different vaccine manufacturers, whereas those for low-to-middle income countries were made primarily for the AstraZeneca-Oxford vaccine, which is lowest in cost and has no special refrigeration needs.[21][22]


Due to the high demand of preorders in 2020–21 by wealthy countries, people in developing countries may be excluded from vaccinations until 2023-24 from the first vaccines to be authorized.[22] On 18 December, the COVAX Facility announced it had established agreements with vaccine manufacturers to supply 1.3 billion doses for 92 low-middle income countries in the first half of 2021.[309] To execute its equitable distribution plan in 2021, COVAX remains in an urgent fundraising campaign to raise US$6.8 billion for vaccine purchases and delivery to participating countries in proportion to their populations.[308]


As many of the efforts on vaccine candidates have open-ended outcomes, including a high potential for failure during human testing, CEPI, WHO, and charitable vaccine organizations, such as the Gates Foundation and GAVI, raised over US$20 billion during the first half of 2020, to fund vaccine development and preparedness for vaccinations, particularly for children in under-developed countries.[52][57][310] CEPI had stated that governments should ensure implementation of a globally-fair allocation system for eventual vaccines, using a coordinated system of manufacturing capacity, financing and purchasing, and indemnification from liability to offset risks taken by vaccine developers.[42] Having been created to monitor fair distribution of infectious disease vaccines to low- and middle-income countries,[311][312] CEPI revised its equitable access policy that was published in February to apply to its COVID‑19 vaccine funding: 1) "prices for vaccines will be set as low as possible for territories that are or may be affected by an outbreak of a disease for which CEPI funding was used to develop a vaccine;" 2) "information, know-how and materials related to vaccine development must be shared with (or transferred to) CEPI" so that it can assume responsibility for vaccine development if a company discontinues expenditures for a promising vaccine candidate; 3) CEPI would have access to, and possible management of, intellectual property rights (i.e., patents) for promising vaccines; 4) "CEPI would receive a share of financial benefits that might accrue from CEPI-sponsored vaccine development, to re-invest in support of its mission to provide global public health benefit"; and 5) data transparency among development partners should maintain the WHO Statement on Public Disclosure of Clinical Trial Results, and require results to be published in open-access publications.[312] Some vaccine manufacturers opposed parts of these proposals.[313][312]


International groups, such as the Centre for Artistic Activism and Universities Allied for Essential Medicines, advocate for equitable access to licensed COVID‑19 vaccines.[314][315] Scientists have encouraged that the WHO, CEPI, corporations, and governments collaborate to assure evidence-based allocation of eventual COVID‑19 vaccines determined on infection risk,[311][312] particularly urgent vaccinations provided first for healthcare workers, vulnerable populations, and children.[38][310][313] Similar to the development of the first polio vaccine that was never patented, an effective COVID‑19 vaccine would be available for production and approval by a number of countries and pharmaceutical manufacturing centers worldwide, therefore allowing for a more even and cost-effective distribution on a global scale.[316]


Sovereignty

Favored distribution of vaccines within one or a few select countries, called "vaccine sovereignty", is a criticism of some of the vaccine development partnerships,[313][311] such as for the AstraZeneca-University of Oxford vaccine candidate, concerning whether there may be prioritized distribution first within the UK and to the "highest bidder" – the United States, which made an advance payment of US$1.2 billion to secure 300 million vaccine doses for Americans, even before the AstraZeneca-Oxford vaccine or a Sanofi vaccine is proved safe or effective.[317][318][319] Concerns exist about whether some countries producing vaccines may impose protectionist controls by export restrictions that would stockpile a COVID‑19 vaccine for their own population.[311]


The Chinese government pledged in May that a successful Chinese vaccine would become a "global, public good", implying enough doses would be manufactured for both national and global distribution.[320] Unlike mRNA vaccines, which have to be stored at subzero temperatures, inactivated vaccines from Sinovac and Sinopharm require ordinary refrigeration[321] and may have more appeal in developing countries.[322]


In June, the Serum Institute of India (SII) – a major manufacturer of global vaccines – reached a licensing agreement with AstraZeneca to make 1 billion doses of vaccine for low-and-middle income countries;[323] of which half of the doses would go to India.[324] Similar preferential homeland distribution may exist if a vaccine is manufactured in Australia.[325]


Licensure

A vaccine licensure occurs after the successful conclusion of the clinical trials program through Phases I–III demonstrating safety, immunogenicity at a specific dose, effectiveness at preventing infection in target populations, and enduring preventive effect.[326] As part of a multinational licensure for a vaccine, the World Health Organization Expert Committee on Biological Standardization developed guidelines of international standards for manufacturing and quality control of vaccines, a process intended as a platform for national regulatory agencies to apply for their own licensure process.[326] Vaccine manufacturers do not receive licensure until a complete clinical package proves the vaccine is safe and has long-term effectiveness, following scientific review by a multinational or national regulatory organization, such as the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA).[327][328]


Upon developing countries adopting WHO guidelines for vaccine development and licensure, each country has its own responsibility to issue a national licensure, and to manage, deploy, and monitor the vaccine throughout its use in each nation.[326] Building trust and acceptance of a licensed vaccine among the public is a task of communication by governments and healthcare personnel to ensure a vaccination campaign proceeds smoothly, saves lives, and enables economic recovery.[329] When a vaccine is licensed, it will initially be in limited supply due to variable manufacturing, distribution, and logistical factors, requiring an allocation plan for the limited supply and which population segments should be prioritized to first receive the vaccine.[329]


World Health Organization

Vaccines developed for multinational distribution via the United Nations Children's Fund (UNICEF) require pre-qualification by WHO to ensure international standards of quality, safety, immunogenicity, and efficacy for adoption by numerous countries.[326]


The process requires manufacturing consistency at WHO-contracted laboratories following Good Manufacturing Practice (GMP).[326] When UN agencies are involved in vaccine licensure, individual nations collaborate by 1) issuing marketing authorization and a national license for the vaccine, its manufacturers, and distribution partners; and 2) conducting postmarketing surveillance, including records for adverse events after the vaccination program. The WHO works with national agencies to monitor inspections of manufacturing facilities and distributors for compliance with GMP and regulatory oversight.[326]


Some countries choose to buy vaccines licensed by reputable national organizations, such as EMA, FDA, or national agencies in other affluent countries, but such purchases typically are more expensive and may not have distribution resources suitable to local conditions in developing countries.[326]


Australia

In October 2020, the Australian Therapeutic Goods Administration (TGA) granted provisional determinations to AstraZeneca Pty Ltd in relation to its COVID‑19 vaccine, ChAdOx1-S [recombinant] and to Pfizer Australia Pty Ltd in relation to its COVID-19 vaccine, BNT162b2 [mRNA].[330][331] Janssen Cilag Pty Ltd was granted a provisional determination in relation to its COVID-19 vaccine, Ad26.COV2.S, in November 2020.[332]


European Union

In the European Union (EU), vaccines for pandemic pathogens, such as seasonal influenza, are licensed EU-wide where all of the member states comply ("centralized"), are licensed for only some member states ("decentralized"), or are licensed on an individual national level.[327] Generally, all EU states follow regulatory guidance and clinical programs defined by the European Committee for Medicinal Products for Human Use (CHMP), a scientific panel of the European Medicines Agency (EMA) responsible for vaccine licensure.[327] The CHMP is supported by several expert groups who assess and monitor the progress of a vaccine before and after licensure and distribution.[327]


In October 2020, the CHMP started 'rolling reviews' of the vaccines known as COVID‑19 Vaccine AstraZeneca (ChAdOx1-SARS-CoV-2) and Pfizer-BioNTech COVID-19 Vaccine (BNT162b2).[333][334][335]


In November 2020, the EMA published a safety monitoring plan and guidance on risk management planning (RMP) for COVID-19 vaccines.[336] The plan outlines how relevant new information emerging after the authorization and uptake of COVID-19 vaccines in the pandemic situation will be collected and promptly reviewed.[336] All RMPs for COVID-19 vaccines will be published on the EMA's website.[336] The EMA published guidance for developers of potential COVID-19 vaccines on the clinical evidence to include in marketing authorization applications.[337]


In November 2020, the CHMP started a rolling review of the Moderna vaccine for COVID-19 known as mRNA-1273.[338]


In December 2020, the EMA received application for conditional marketing authorizations (CMA) for the mRNA vaccines BNT162b2 and mRNA1273 (Moderna Covid-19 vaccine).[141][339] The assessments of the vaccines are scheduled to proceed under accelerated timelines with the possibility of opinions issued within weeks.[141][339][340][341]


In December 2020, the CHMP started a rolling review of the Ad26.COV2.S COVID-19 vaccine from Janssen-Cilag International N.V.[199]


United States

Under the FDA, the process of establishing evidence for vaccine clinical safety and efficacy is the same as for the approval process for prescription drugs.[342] If successful through the stages of clinical development, the vaccine licensing process is followed by a Biologics License Application which must provide a scientific review team (from diverse disciplines, such as physicians, statisticians, microbiologists, chemists) a comprehensive documentation for the vaccine candidate having efficacy and safety throughout its development. Also during this stage, the proposed manufacturing facility is examined by expert reviewers for GMP compliance, and the label must have compliant description to enable health care providers definition of vaccine specific use, including its possible risks, to communicate and deliver the vaccine to the public.[342]


The Advisory Committee on Immunization Practices voted on 2 December, that the first doses of the vaccine should be prioritized for health care workers and residents and staff of nursing homes.[343] The board will make guidance who should receive the vaccine next as production increases, which will include older adults, emergency responders, teachers, and essential workers less able to socially distance, and people with comorbidities. However, states will make the final plans for prioritization, distribution, and logistics of vaccinating everyone as supply becomes available.[344] After licensure, monitoring of the vaccine and its production, including periodic inspections for GMP compliance, continue as long as the manufacturer retains its license, which may include additional submissions to the FDA of tests for potency, safety, and purity for each vaccine manufacturing step.[342]


Postmarketing surveillance

Until a vaccine is in use for the general population, all potential adverse events from the vaccine may not be known, requiring manufacturers to conduct Phase IV studies for postmarketing surveillance of the vaccine while it is used widely in the public.[326][342] The WHO works with UN member states to implement postlicensing surveillance.[326] The FDA relies on a Vaccine Adverse Event Reporting System to monitor safety concerns about a vaccine throughout its use in the American public.[342]


Commercialization

By June 2020, tens of billions of dollars were invested by corporations, governments, international health organizations, and university research groups to develop dozens of vaccine candidates and prepare for global vaccination programs to immunize against COVID‑19 infection.[38][310][313][317] The corporate investment and need to generate value for public shareholders raised concerns about a "market-based approach" in vaccine development, costly pricing of eventual licensed vaccines, preferred access for distribution first to affluent countries, and sparse or no distribution to where the pandemic is most aggressive, as predicted for densely-populated, impoverished countries unable to afford vaccinations.[38][62][313] The collaboration of the University of Oxford with AstraZeneca (a global pharmaceutical company based in the UK) raised concerns about price and sharing of eventual profits from international vaccine sales, arising from whether the British government and university as public partners had commercialization rights.[317] AstraZeneca stated that initial pricing of its vaccine would not include a profit margin for the company while the pandemic was still expanding.[317]


In early June, AstraZeneca made a US$750 million deal allowing CEPI and GAVI to manufacture and distribute 300 million doses if its Oxford vaccine candidate proves safe and effective, reportedly increasing the company's total production capacity to over 2 billion doses per year.[323] Commercialization of pandemic vaccines is a high-risk business venture, potentially losing billions of dollars in development and pre-market manufacturing costs if the candidate vaccines fail to be safe and effective.[38][61][62][310] The multinational pharmaceutical company Pfizer indicated it was not interested in a government partnership, which would be a "third party" slowing progress in Pfizer's vaccine program.[345] Further, there are concerns that rapid-development programs – like the Operation Warp Speed plan of the United States – are choosing vaccine candidates mainly for their manufacturing advantages to shorten the development timeline, rather than for the most promising vaccine technology having safety and efficacy.[345]


Supply chain

During and after 2021, deploying a COVID-19 vaccine may require worldwide transport and tracking of 10–19 billion vial doses, an effort readily becoming the largest supply chain challenge in history.[35][346][324] As of September 2020, supply chain and logistics experts expressed concern that international and national networks for distributing a licensed vaccine were not ready for the volume and urgency, due mainly to deterioration of resources during 2020 pandemic lockdowns and downsizing that degraded supply capabilities.[346][347][348] Addressing the worldwide challenge faced by coordinating numerous organizations – the COVAX partnership, global pharmaceutical companies, contract vaccine manufacturers, inter- and intranational transport, storage facilities, and health organizations in individual countries – Seth Berkley, chief executive of GAVI, stated: "Delivering billions of doses of vaccine to the entire world efficiently will involve hugely complex logistical and programmatic obstacles all the way along the supply chain."[349]


As an example highlighting the immensity of the challenge, the International Air Transport Association stated that 8,000 Boeing 747 cargo planes – implemented with equipment for precision vaccine cold storage – would be needed to transport just one dose for people in the more than 200 countries experiencing the COVID‑19 pandemic.[350] GAVI states that "with a fast-moving pandemic, no one is safe, unless everyone is safe."[92]


In contrast to the multibillion-dollar investment in vaccine technologies and early-stage clinical research, the post-licensing supply chain for a vaccine has not received the same planning, coordination, security or investment.[346][347][351] A major concern is that resources for vaccine distribution in low- to middle-income countries, particularly for vaccinating children, are inadequate or non-existent, but could be improved with cost efficiencies if procurement and distribution were centralized regionally or nationally.[92][352] In September, the COVAX partnership included 172 countries coordinating plans to optimize the supply chain for a COVID‑19 vaccine,[353] and the United Nations Children's Fund joined with COVAX to prepare the financing and supply chain for vaccinations of children in 92 developing countries.[354][355]


Logistics

Logistics vaccination services assure necessary equipment, staff, and supply of licensed vaccines across international borders.[356] Central logistics include vaccine handling and monitoring, cold chain management, and safety of distribution within the vaccination network.[357] The purpose of the COVAX Facility is to centralize and equitably administer logistics resources among participating countries, merging manufacturing, transport, and overall supply chain infrastructure.[92][351] Included are logistics tools for vaccine forecasting and needs estimation, in-country vaccine management, potential for wastage, and stock management.[357]


Other logistics factors conducted internationally during distribution of a COVID‑19 vaccine may include:[346][358][359]


visibility and traceability by barcodes for each vaccine vial

sharing of supplier audits

sharing of chain of custody for a vaccine vial from manufacturer to the individual being vaccinated

use of vaccine temperature monitoring tools

temperature stability testing and assurance

new packaging and delivery technologies

stockpiling

coordination of supplies within each country (personal protective equipment, diluent, syringes, needles, rubber stoppers, refrigeration fuel or power sources, waste-handling, among others)

communications technology

environmental impacts in each country

A logistics shortage in any one step may derail the whole supply chain, according to one vaccine developer.[360] If the vaccine supply chain fails, the economic and human costs of the pandemic may be extended for years.[348]


Manufacturing capacity

By August 2020, when only a few vaccine candidates were in Phase III trials and were many months away from establishing safety and efficacy, numerous governments pre-ordered more than two billion doses at a cost of more than US$5 billion.[324][360][361] Pre-orders from the British government for 2021 were for five vaccine doses per person, a number dispiriting to organizations like the WHO and GAVI which are promoting fair and equitable access worldwide, especially for developing countries.[324] In September, CEPI was financially supporting basic and clinical research for nine vaccine candidates, with nine more in evaluation, under financing commitments to manufacture two billion doses of three licensed vaccines by the end of 2021.[353] Before 2022, 7–10 billion COVID‑19 vaccine doses may be manufactured worldwide, but the sizable pre-orders by affluent countries – called "vaccine nationalism" – threaten vaccine availability for poorer nations.[35][360][324]


After joining COVAX in October, China initially shared that it would produce 600 million vaccine doses before the end of 2020 and another one billion doses in 2021, although it was unsure how many would be for the country's own population of 1.4 billion.[362] Sinopharm said it may have the capacity to produce more than 1 billion doses in 2021,[363] while its Dubai partner G42 Healthcare aimed to produce up to 100 million doses in 2021 focused on the middle east.[364] Sinovac aimed to complete a second production facility by the end of 2020 to increase production of CoronaVac to 600 million doses from 300 million,[365] while its Brazilian partner Instituto Butantan planned to produce 100 million doses[366] and its Indonesian partner Bio Farma planned to produce up to 250 million doses of CoronaVac a year.[367]


The Serum Institute of India plans to produce at least one billion vaccine doses, although the institute has stated that half the doses will be used in India.[324]


AstraZeneca CEO, Pascal Soriot, stated: "The challenge is not making the vaccine itself, it's filling vials. There just aren't enough vials in the world."[368] Preparing for high demand in manufacturing vials, an American glass producer invested $163 million in July for a vial factory.[369] Glass availability for vial manufacturing and contaminant control are issues of concern,[370] indicating higher production costs with lower profit potential for developers amid demands for vaccines to be affordable.[92][324][348]


Vaccines must be handled and transported using international regulations, be maintained at controlled temperatures that vary across vaccine technologies, and be used for immunization before deterioration in storage.[324][360] The scale of the COVID‑19 vaccine supply chain is expected to be vast to ensure delivery worldwide to vulnerable populations.[35][347] Priorities for preparing facilities for such distribution include temperature-controlled facilities and equipment, optimizing infrastructure, training immunization staff, and rigorous monitoring.[347][349][354] RFID technologies are being implemented to track and authenticate a vaccine dose from the manufacturer along the entire supply chain to the vaccination.[371]


In September 2020, Grand River Aseptic Manufacturing agreed with Johnson & Johnson to support the manufacture of its vaccine candidate, including technology transfer and fill and finish manufacturing.[372] In October 2020, it was announced that the Moderna vaccine candidate will be manufactured in Visp, Switzerland by its partner Lonza Group, which plans to produce the first doses in December 2020.[373] The newly built 2,000-square-metre facility will ramp up production to 300 million doses annually. The ingredient will be shipped frozen at −70 °C to Spain's Laboratorios Farmacéuticos Rovi SA for the final stage of manufacturing.[373] Lonza's site in Portsmouth, New Hampshire, aims to start making vaccine ingredients exclusively for the U.S. as early as November.[373]


Cold chain

See also: ULT freezer § Use for COVID-19 vaccine storage

Vaccines (and adjuvants) are inherently unstable during temperature changes, requiring cold chain management throughout the entire supply chain, typically at temperatures of 2–8 °C (36–46 °F).[359][374] Because COVID‑19 vaccine technologies are varied among several novel technologies, there are new challenges for cold chain management, with some vaccines that are stable while frozen but labile to heat, while others should not be frozen at all, and some are stable across temperatures.[374] Freezing damage and inadequate training of personnel in the local vaccination process are major concerns.[375] If more than one COVID‑19 vaccine is approved, the vaccine cold chain may have to accommodate all these temperature sensitivities across different countries with variable climate conditions and local resources for temperature maintenance.[374] Sinopharm and Sinovac's vaccines are examples of inactivated vaccines in Phase III testing which can be transported using existing cold chain systems at 2–8 °C (36–46 °F).[376][377]


modRNA vaccine technologies in development may be more difficult to manufacture at scale and control degradation, requiring ultracold storage and transport.[348] As examples, Moderna's RNA vaccine candidate requires cold chain management just above freezing temperatures between 2 and 8 °C (36 and 46 °F) with limited storage duration (30 days),[378] but the Pfizer-BioNTech RNA candidate requires storage between −80 and −60 °C (−112 and −76 °F),[274] or colder throughout deployment until vaccination.[379][380]


After a vaccine vial is punctured to administer a dose, it is viable for only six hours, then must be discarded, requiring attention to local management of cold storage and vaccination processes.[35][381] Because the COVID‑19 vaccine will likely be in short supply for many locations during early deployment, vaccination staff will have to avoid spoilage and waste, which typically are as much as 30% of the supply.[346][381] The cold chain is further challenged by the type of local transportation for the vaccines in rural communities, such as by motorcycle or delivery drone, need for booster doses, use of diluents, and access to vulnerable populations, such as healthcare staff, children and the elderly.[35][354][382]


Air and land transport

Coordination of international air cargo is an essential component of time- and temperature-sensitive distribution of COVID‑19 vaccines, but, as of September 2020, the air freight network is not prepared for multinational deployment.[347][350][383] "Safely delivering COVID‑19 vaccines will be the mission of the century for the global air cargo industry. But it won't happen without careful advance planning. And the time for that is now. We urge governments to take the lead in facilitating cooperation across the logistics chain so that the facilities, security arrangements and border processes are ready for the mammoth and complex task ahead," said IATA's Director General and CEO, Alexandre de Juniac, in September 2020.[383]


For the severe reduction in passenger air traffic during 2020, airlines downsized personnel, trimmed destination networks, and put aircraft into long-term storage.[347][383] As the lead agencies for procurement and supply of the COVID-19 vaccine within the WHO COVAX Facility, GAVI and UNICEF are preparing for the largest and fastest vaccine deployment ever, necessitating international air freight collaboration, customs and border control, and possibly as many as 8,000 cargo planes to deliver just one vaccine dose to multiple countries.[354][383]


Two of the first approved vaccines, Pfizer and BioNTech's Pfizer-BioNTech COVID-19 vaccine and Moderna's mRNA-1273, must be kept cold during transport. Keeping the temperatures sufficiently low is accomplished with specially-designed containers[a] and dry ice, but dry ice is only allowed in limited quantities on airplanes as the gases released via sublimation may be toxic. In the United States, the Federal Aviation Administration (FAA) limits the amount of dry ice on a Boeing 777-224 to 3,000 lb (1,400 kg), but it temporarily allowed United Airlines to transport up to 15,000 lb (6,800 kg)—nearly 1 million doses—between Brussels and Chicago. The CDC has tasked McKesson with vaccine distribution in the US; the company will handle all major vaccines except Pfizer's. American Airlines, Boeing, and Delta Airlines are also working to increase dry ice transportation capacity, and American, Delta, and United each operate their own cold storage networks in the US. FedEx and UPS have installed ultra-cold freezers at air cargo hubs in Europe and North America, and UPS can manufacture 1,200 lb (540 kg) of dry ice per hour.[385]


Security and corruption

Medicines are the world's largest fraud market, worth some $200 billion per year, making the widespread demand for a COVID-19 vaccine vulnerable to counterfeit, theft, scams, and cyberattacks throughout the supply chain.[351][386] The vaccine has been referred to as "the most valuable asset on earth"; Interpol called it "liquid gold" and warned of an "onslaught of all types of criminal activity".[387] Anticorruption, transparency, and accountability safeguards are being established to reduce and eliminate corruption of COVID‑19 vaccine supplies.[386][388] Absence of harmonized regulatory frameworks among countries, including low technical capacity, constrained access, and ineffective capability to identify and track genuine vs. counterfeit vaccines, may be life-threatening for vaccine recipients, and would potentially perpetuate the COVID‑19 pandemic.[386] Tracking system technologies for packaging are being used by manufacturers to trace vaccine vials across the supply chain,[351] and to use digital and biometric tools to assure security for vaccination teams.[371][389] In December 2020, Interpol warned that organized crime could infiltrate the vaccine supply chain, steal product through physical means, and data theft, or even offer counterfeit vaccine kits.[390] Further, vaccines which require constant freezing temperatures are also susceptible to sabotage.[387]


GPS devices will be used in the United States to track the vaccines. In Colorado, the vaccine shipments will be escorted by Colorado State Patrol officers from Denver International Airport to the state's eight distribution points; the exact plans are confidential and law enforcement will "maintain a low-key profile".[384]


Peripheral businesses may also be affected. An IBM security analyst told The New York Times that petrochemical companies are being targeted by hackers due to their central role in producing dry ice.[387]


National infrastructure

The WHO has implemented an "Effective Vaccine Management" system,[391] which includes constructing priorities to prepare national and subnational personnel and facilities for vaccine distribution, including:


Trained staff to handle time- and temperature-sensitive vaccines

Robust monitoring capabilities to ensure optimal vaccine storage and transport

Temperature-controlled facilities and equipment

Traceability

Security

Border processes for efficient handling and customs clearance within individual countries may include:[356][391]


Facilitating flight and landing permits

Exempting flight crews from quarantine requirements

Facilitating flexible operations for efficient national deployment

Granting arrival priority to maintain vaccine temperature requirements

Liability

On 4 February 2020, US Secretary of Health and Human Services Alex Azar published a notice of declaration under the Public Readiness and Emergency Preparedness Act for medical countermeasures against COVID‑19, covering "any vaccine, used to treat, diagnose, cure, prevent, or mitigate COVID‑19, or the transmission of SARS-CoV-2 or a virus mutating therefrom", and stating that the declaration precludes "liability claims alleging negligence by a manufacturer in creating a vaccine, or negligence by a health care provider in prescribing the wrong dose, absent willful misconduct".[392] The declaration is effective in the United States through 1 October 2024.[392]


Misinformation

Main article: Misinformation related to the COVID-19 pandemic § Vaccine misinformation

Social media posts have previously promoted a conspiracy theory that a COVID‑19 vaccine was already available when it was not. The patents cited by these various social media posts had references to existing patents for genetic sequences and vaccines for other strains such as the SARS coronavirus, but not for COVID‑19.[393][394]


On 21 May 2020, the FDA made public the cease-and-desist notice it had sent to North Coast Biologics, a Seattle-based company that had been selling a purported "nCoV19 spike protein vaccine".[395]


Society and culture

Brand names

The vaccine manufacturers are waiting for full approval to name their vaccines.[396][397] The brand name of the Pfizer‑BioNTech COVID‑19 vaccine approved in Switzerland is Comirnaty.[16]


See also

virus icon Coronavirus disease 2019 portal

icon Medicine portal

icon Modern history portal

icon Viruses portal

Current events portal

2009 swine flu pandemic vaccine

COVID-19 drug development

COVID-19 drug repurposing research

Phases of clinical research

Respiratory disease

References

 "UK medicines regulator gives approval for first UK COVID-19 vaccine". Medicines and Healthcare Products Regulatory Agency, Government of the UK. 2 December 2020. Retrieved 2 December 2020.

 "Bahrain second in the world to approve the Pfizer/BioNTech Covid-19 vaccine". Bahrain News Agency. 4 December 2020. Retrieved 9 December 2020.

 "UAE: Ministry of Health announces 86 per cent vaccine efficacy". Gulf News. Retrieved 9 December 2020.

 "Regulatory Decision Summary - Pfizer-BioNTech COVID-19 Vaccine". Health Canada, Government of Canada. 9 December 2020. Retrieved 9 December 2020.

 "Coronavirus: Saudi Arabia approves Pfizer COVID-19 vaccine for use". Al Arabiya English. 10 December 2020. Retrieved 10 December 2020.

 Thomas K (20 November 2020). "F.D.A. Clears Pfizer Vaccine, and Millions of Doses Will Be Shipped Right Away". The New York Times. Retrieved 11 December 2020.

 Daina Beth Solomon; Noe Torres (11 December 2020). "Mexico approves emergency use of Pfizer's COVID-19 vaccine". Reuters. Retrieved 12 December 2020.

 "Kuwait authorizes emergency use of Pfizer-BioNTech COVID-19 vaccine". Arab News. 13 December 2020. Retrieved 15 December 2020.

 "Singapore approves use of Pfizer's COVID-19 vaccine". AP NEWS. 14 December 2020. Retrieved 15 December 2020.

 "Jordan approves Pfizer-BioNTech Covid vaccine". France 24. 15 December 2020. Retrieved 15 December 2020.

 "Oman issues licence to import Pfizer BioNTech Covid vaccine - TV". Reuters. 15 December 2020. Retrieved 16 December 2020.

 "Arcsa autoriza ingreso al país de vacuna Pfizer-BioNTech para el Covid-19 – Agencia Nacional de Regulación, Control y Vigilancia Sanitaria" (in Spanish). Retrieved 17 December 2020.

 "Costa Rica authorizes Pfizer-BioNTech coronavirus vaccine". The Tico Times. 16 December 2020. Retrieved 16 December 2020.

 "Panama approves Pfizer's COVID-19 vaccine - health ministry". finance.yahoo.com. Retrieved 16 December 2020.

 "Chile approves Pfizer-BioNTech Covid-19 vaccine for emergency use". The Straits Times. 17 December 2020. Retrieved 17 December 2020.

 "Swissmedic grants authorisation for the first COVID-19 vaccine in Switzerland" (Press release). Swiss Agency for Therapeutic Products (Swissmedic). 19 December 2020. Retrieved 19 December 2020.

 Campbell, Denis (16 December 2020). "138,000 people in UK receive Covid vaccine in first week". The Guardian.

 Thomas K, LaFraniere S, Weiland N, Goodnough A, Haberman M (12 December 2020). "F.D.A. Clears Pfizer Vaccine, and Millions of Doses Will Be Shipped Right Away". The New York Times. Retrieved 12 December 2020.

 "FDA Takes Additional Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for Second COVID-19 Vaccine". U.S. Food and Drug Administration (FDA) (Press release). Retrieved 18 December 2020.

 Lovelace Jr B (19 December 2020). "FDA approves second Covid vaccine for emergency use as it clears Moderna's for U.S. distribution". CNBC. Retrieved 19 December 2020.

 Mullard, Asher (30 November 2020). "How COVID vaccines are being divvied up around the world Canada leads the pack in terms of doses secured per capita". Nature. doi:10.1038/d41586-020-03370-6. PMID 33257891. S2CID 227246811. Retrieved 11 December 2020.

 So AD, Woo J (December 2020). "Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis". BMJ: m4750. doi:10.1136/bmj.m4750. ISSN 1756-1833.

 Cavanagh D (December 2003). "Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus". Avian Pathology. 32 (6): 567–82. doi:10.1080/03079450310001621198. PMC 7154303. PMID 14676007.

 Gao W, Tamin A, Soloff A, D'Aiuto L, Nwanegbo E, Robbins PD, et al. (December 2003). "Effects of a SARS-associated coronavirus vaccine in monkeys". Lancet. 362 (9399): 1895–96. doi:10.1016/S0140-6736(03)14962-8. PMC 7112457. PMID 14667748.

 Kim E, Okada K, Kenniston T, Raj VS, AlHajri MM, Farag EA, et al. (October 2014). "Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice". Vaccine. 32 (45): 5975–82. doi:10.1016/j.vaccine.2014.08.058. PMC 7115510. PMID 25192975.

 Greenough TC, Babcock GJ, Roberts A, Hernandez HJ, Thomas WD, Coccia JA, et al. (February 2005). "Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice". The Journal of Infectious Diseases. 191 (4): 507–14. doi:10.1086/427242. PMC 7110081. PMID 15655773.

 Tripp RA, Haynes LM, Moore D, Anderson B, Tamin A, Harcourt BH, et al. (September 2005). "Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins". Journal of Virological Methods. 128 (1–2): 21–28. doi:10.1016/j.jviromet.2005.03.021. PMC 7112802. PMID 15885812.

 Roberts A, Thomas WD, Guarner J, Lamirande EW, Babcock GJ, Greenough TC, et al. (March 2006). "Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters". The Journal of Infectious Diseases. 193 (5): 685–92. doi:10.1086/500143. PMC 7109703. PMID 16453264.

 Jiang S, Lu L, Du L (January 2013). "Development of SARS vaccines and therapeutics is still needed". Future Virology. 8 (1): 1–2. doi:10.2217/fvl.12.126. PMC 7079997. PMID 32201503.

 "SARS (severe acute respiratory syndrome)". National Health Service. 5 March 2020. Archived from the original on 9 March 2020. Retrieved 31 January 2020.

 Shehata MM, Gomaa MR, Ali MA, Kayali G (January 2016). "Middle East respiratory syndrome coronavirus: a comprehensive review". Frontiers of Medicine. 10 (2): 120–36. doi:10.1007/s11684-016-0430-6. PMC 7089261. PMID 26791756.

 Butler D (October 2012). "SARS veterans tackle coronavirus". Nature. 490 (7418): 20. Bibcode:2012Natur.490...20B. doi:10.1038/490020a. PMID 23038444.

 Modjarrad K, Roberts CC, Mills KT, Castellano AR, Paolino K, Muthumani K, et al. (September 2019). "Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial". The Lancet. Infectious Diseases. 19 (9): 1013–22. doi:10.1016/S1473-3099(19)30266-X. PMC 7185789. PMID 31351922.

 Yong CY, Ong HK, Yeap SK, Ho KL, Tan WS (2019). "Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus". Frontiers in Microbiology. 10: 1781. doi:10.3389/fmicb.2019.01781. PMC 6688523. PMID 31428074.

 Gates B (30 April 2020). "The vaccine race explained: What you need to know about the COVID-19 vaccine". The Gates Notes. Archived from the original on 14 May 2020. Retrieved 2 May 2020.

 "World Health Organization timeline – COVID-19". World Health Organization. 27 April 2020. Archived from the original on 29 April 2020. Retrieved 2 May 2020.

 Thanh Le T, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M, et al. (9 April 2020). "The COVID-19 vaccine development landscape". Nature Reviews Drug Discovery. 19 (5): 305–06. doi:10.1038/d41573-020-00073-5. ISSN 1474-1776. PMID 32273591.

 Gates B (February 2020). "Responding to Covid-19: A once-in-a-century pandemic?". The New England Journal of Medicine. 382 (18): 1677–79. doi:10.1056/nejmp2003762. PMID 32109012.

 Fauci AS, Lane HC, Redfield RR (March 2020). "Covid-19: Navigating the uncharted". The New England Journal of Medicine. 382 (13): 1268–69. doi:10.1056/nejme2002387. PMC 7121221. PMID 32109011.

 Grenfell R, Drew T (14 February 2020). "Here's why the WHO says a coronavirus vaccine is 18 months away". Business Insider. Retrieved 11 November 2020.

 "Update on WHO Solidarity Trial – Accelerating a safe and effective COVID-19 vaccine". World Health Organization. 27 April 2020. Archived from the original on 30 April 2020. Retrieved 2 May 2020. It is vital that we evaluate as many vaccines as possible as we cannot predict how many will turn out to be viable. To increase the chances of success (given the high level of attrition during vaccine development), we must test all candidate vaccines until they fail. [The] WHO is working to ensure that all of them have the chance of being tested at the initial stage of development. The results for the efficacy of each vaccine are expected within three to six months and this evidence, combined with data on safety, will inform decisions about whether it can be used on a wider scale.

 Yamey G, Schäferhoff M, Hatchett R, Pate M, Zhao F, McDade KK (May 2020). "Ensuring global access to COVID‑19 vaccines". Lancet. 395 (10234): 1405–06. doi:10.1016/S0140-6736(20)30763-7. PMC 7271264. PMID 32243778. CEPI estimates that developing up to three vaccines in the next 12–18 months will require an investment of at least US$2 billion. This estimate includes Phase 1 clinical trials of eight vaccine candidates, progression of up to six candidates through Phase 2 and 3 trials, completion of regulatory and quality requirements for at least three vaccines, and enhancing global manufacturing capacity for three vaccines.

 Schmidt C (1 June 2020). "Genetic Engineering Could Make a COVID-19 Vaccine in Months Rather Than Years". Scientific American. Archived from the original on 11 October 2020. Retrieved 26 August 2020.

 Le TT, Cramer JP, Chen R, Mayhew S (4 September 2020). "Evolution of the COVID-19 vaccine development landscape". Nature Reviews Drug Discovery. 19 (10): 667–68. doi:10.1038/d41573-020-00151-8. ISSN 1474-1776. PMID 32887942. S2CID 221503034.

 Fox C, Kelion L (16 July 2020). "Russian spies 'target coronavirus vaccine'". BBC News Online. Archived from the original on 11 October 2020. Retrieved 1 August 2020.

 "What is the ACT Accelerator?". World Health Organization. 2020. Archived from the original on 25 September 2020. Retrieved 29 August 2020.

 "What is COVAX?". GAVI. 1 September 2020. Retrieved 11 December 2020.

 "COVAX: CEPI's response to COVID-19". Coalition for Epidemic Preparedness Innovations (CEPI). 2020. Retrieved 15 December 2020.

 "New vaccines for a safer world". CEPI. 2020. Retrieved 15 December 2020.

 "Our portfolio: partnerships to develop vaccines against COVID-19". CEPI. 2020. Retrieved 15 December 2020.

 "Global equitable access to COVID-19 vaccines estimated to generate economic benefits of at least US$ 153 billion in 2020–21, and US$ 466 billion by 2025, in 10 major economies, according to new report by the Eurasia Group". World Health Organization. 4 December 2020. Retrieved 11 December 2020.

 Wake D (4 May 2020). "EU spearheads $8 billion virus fundraiser". Yahoo Finance. Archived from the original on 29 June 2020. Retrieved 4 May 2020.

 "More than 150 countries engaged in COVID-19 vaccine global access facility". World Health Organization. 15 July 2020. Archived from the original on 15 July 2020. Retrieved 25 July 2020. COVAX is the only truly global solution to the COVID-19 pandemic. For the vast majority of countries, whether they can afford to pay for their own doses or require assistance, it means receiving a guaranteed share of doses and avoiding being pushed to the back of the queue, as we saw during the H1N1 pandemic a decade ago. Even for those countries that are able to secure their own agreements with vaccine manufacturers, this mechanism represents, through its world-leading portfolio of vaccine candidates, a means of reducing the risks associated with individual candidates failing to show efficacy or gain licensure.

 "GloPID: Novel coronavirus COVID-19". glopid-r.org. Archived from the original on 2 May 2020. Retrieved 2 May 2020. GloPID-R Members and other major players involved in infectious disease outbreaks worldwide reacted rapidly to this emerging epidemic, working closely with WHO to identify the specific funding research priorities needed to tackle the disease.

 "Government of Canada's research response to COVID-19". Government of Canada. 23 April 2020. Archived from the original on 13 May 2020. Retrieved 4 May 2020.

 "ISARIC: COVID-19 clinical research resources". ISARIC. 27 April 2020. Archived from the original on 30 March 2020. Retrieved 2 May 2020.

 "Global Vaccine Summit 2020: World leaders make historic commitments to provide equal access to vaccines for all". Global Alliance for Vaccines and Immunisation. 4 June 2020. Archived from the original on 6 June 2020. Retrieved 4 June 2020.

 "Bill & Melinda Gates Foundation pledges US$1.6 billion to Gavi, the Vaccine Alliance, to protect the next generation with lifesaving vaccines" (Press release). The Bill & Melinda Gates Foundation. 4 June 2020. Archived from the original on 4 June 2020. Retrieved 4 June 2020 – via PR Newswire.

 Yamada, Haley; Schlosberg, Jon; Tienabeso, Seni (10 December 2020). "Bill and Melinda Gates Foundation announces $250 million COVID vaccine commitment". ABC News - Technology. Retrieved 11 December 2020.

 "Bill and Melinda Gates call for collaboration, continued innovation to overcome challenges of delivering COVID-19 scientific breakthroughs to the world". Bill & Melinda Gates Foundation. 9 December 2020. Retrieved 11 December 2020.

 Steenhuysen J, Eisler P, Martell A, Nebehay S (27 April 2020). "Special Report: Countries, companies risk billions in race for coronavirus vaccine". Reuters. Archived from the original on 15 May 2020. Retrieved 2 May 2020.

 Sanger DE, Kirkpatrick DD, Zimmer C, Thomas K, Wee S (2 May 2020). "With Pressure Growing, Global Race for a Vaccine Intensifies". The New York Times. ISSN 0362-4331. Archived from the original on 11 May 2020. Retrieved 2 May 2020.

 Hamilton IA (1 May 2020). "Bill Gates thinks there are 8 to 10 promising coronavirus vaccine candidates and one could be ready in as little as 9 months". Business Insider. Archived from the original on 16 May 2020. Retrieved 2 May 2020.

 Jackson, Nick (28 September 2020). "Why we need a "portfolio approach" to COVID-19 vaccine development". CEPI. Retrieved 15 December 2020.

 "CEPI's COVID-19 vaccine portfolio". CEPI. 2020. Retrieved 15 December 2020.

 "CEPI and SK bioscience extend collaboration to develop 'next generation' COVID-19 vaccine". CEPI. 9 December 2020. Retrieved 15 December 2020.

 Abedi M (23 March 2020). "Canada to spend $192M on developing COVID-19 vaccine". Global News. Archived from the original on 9 April 2020. Retrieved 24 March 2020.

 "Government of Canada funds 49 additional COVID-19 research projects – Details of the funded projects". Government of Canada. 23 March 2020. Archived from the original on 22 March 2020. Retrieved 23 March 2020.

 Aiello R (4 May 2020). "'A global challenge': PM Trudeau commits $850 million to global fight against COVID-19". CTV News. Archived from the original on 10 May 2020. Retrieved 4 May 2020.

 Takada N, Satake M (2 May 2020). "US and China unleash wallets in race for coronavirus vaccine". Nikkei Asian Review. Archived from the original on 10 May 2020. Retrieved 3 May 2020.

 Yuliya Talmazan, Keir Simmons, Laura Saravia (18 May 2020). "China's Xi announces $2B for coronavirus response as WHO faces calls for investigation". NBC News. Archived from the original on 18 May 2020. Retrieved 18 May 2020.

 Ore D (23 July 2020). "Mexico says China plans $1 billion loan to ease Latam access to virus vaccine". Reuters. Archived from the original on 25 September 2020. Retrieved 16 August 2020.

 "China promises Mekong neighbours access to Chinese Covid-19 vaccine". South China Morning Post. 24 August 2020. Archived from the original on 25 September 2020. Retrieved 24 August 2020.

 "CEPI: Our vaccine and platform portfolio". Coalition for Epidemic Preparedness Innovation (CEPI). 30 April 2020. Archived from the original on 7 May 2020. Retrieved 3 May 2020.

 "CEPI collaborates with the Institut Pasteur in a consortium to develop COVID-19 vaccine". Coalition for Epidemic Preparedness Innovations. 19 March 2020. Archived from the original on 22 March 2020. Retrieved 23 March 2020.

 "Coronavirus: Commission offers financing to innovative vaccines company CureVac". European Commission. 16 March 2020. Archived from the original on 19 March 2020. Retrieved 19 March 2020.

 "Corona-Impfstoff: Bundesregierung beteiligt sich an Impfstoffhersteller CureVac". www.spiegel.de (in German). Der Spiegel. Archived from the original on 16 June 2020. Retrieved 15 June 2020.

 Morriss E (22 April 2020). "Government launches coronavirus vaccine taskforce as human clinical trials start". Pharmafield. Archived from the original on 17 June 2020. Retrieved 3 May 2020.

 Gartner A, Roberts L (3 May 2020). "How close are we to a coronavirus vaccine? Latest news on UK trials". The Telegraph. ISSN 0307-1235. Archived from the original on 4 May 2020. Retrieved 3 May 2020.

 "Landmark partnership announced for development of COVID-19 vaccine". University of Oxford. 30 April 2020. Archived from the original on 13 May 2020. Retrieved 3 May 2020.

 Kuznia R, Polglase K, Mezzofiore G (1 May 2020). "In quest for vaccine, US makes 'big bet' on company with unproven technology". CNN. Archived from the original on 13 May 2020. Retrieved 2 May 2020.

 Lee CE, Welker K, Perlmutter-Gumbiner E (1 May 2020). "Health officials eyeing at least one of 14 potential coronavirus vaccines to fast-track". NBC News. Archived from the original on 11 May 2020. Retrieved 2 May 2020.

 Cohen J (15 May 2020). "U.S. 'Warp Speed' vaccine effort comes out of the shadows". Science. 368 (6492): 692–93. Bibcode:2020Sci...368..692C. doi:10.1126/science.368.6492.692. ISSN 0036-8075. PMID 32409451.

 Justin Sink, Jordan Fabian, Riley Griffin (15 May 2020). "Trump introduces 'Warp Speed' leaders to hasten COVID-19 vaccine". Bloomberg. Archived from the original on 21 May 2020. Retrieved 15 May 2020.

 Riley Griffith, Jennifer Jacobs (3 June 2020). "White House Works With Seven Drugmakers in 'Warp Speed' Push". Bloomberg. Archived from the original on 3 June 2020. Retrieved 4 June 2020.

 "Fact-checking the battle for credit over Pfizer's vaccine announcement". CNN. Retrieved 13 November 2020. Pfizer is one of various vaccine manufacturers participating in Operation Warp Speed as a supplier of a potential COVID-19 vaccine," Castillo said in an email. "While Pfizer did reach an advanced purchase agreement with the U.S. government, the company did not accept (Biomedical Advanced Research and Development Authority) funding for the research and development process. All the investment for R&D was made by Pfizer at risk. Dr. Jansen was emphasizing that last point.

 "Draft landscape of COVID 19 candidate vaccines". World Health Organization. 10 December 2020. Retrieved 11 December 2020.

 "An international randomised trial of candidate vaccines against COVID-19: Outline of Solidarity vaccine trial" (PDF). World Health Organization. 9 April 2020. Archived (PDF) from the original on 12 May 2020. Retrieved 9 May 2020.

 Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, et al. (February 2018). "Adaptive designs in clinical trials: why use them, and how to run and report them". BMC Medicine. 16 (1): 29. doi:10.1186/s12916-018-1017-7. PMC 5830330. PMID 29490655.

 "Adaptive designs for clinical trials of drugs and biologics: Guidance for industry". U.S. Food and Drug Administration (FDA). 1 November 2019. Archived from the original on 13 December 2019. Retrieved 3 April 2020.

 McGrail S (15 April 2020). "Sanofi, GSK partner to develop adjuvanted COVID-19 vaccine". PharmaNewsIntelligence. Archived from the original on 9 May 2020. Retrieved 4 May 2020.

 "COVAX: Ensuring global equitable access to COVID-19 vaccines". GAVI. 2020. Archived from the original on 25 September 2020. Retrieved 28 August 2020.

 "R&D Blueprint: A coordinated global research roadmap – 2019 novel coronavirus" (PDF). World Health Organization. 1 March 2020. Archived (PDF) from the original on 15 May 2020. Retrieved 10 May 2020.

 Jeong-ho L, Zheng W, Zhou L (26 January 2020). "Chinese scientists race to develop vaccine as coronavirus death toll jumps". South China Morning Post. Archived from the original on 26 January 2020. Retrieved 28 January 2020.

 Wee S (4 May 2020). "China's coronavirus vaccine drive empowers a troubled industry". The New York Times. ISSN 0362-4331. Archived from the original on 4 May 2020. Retrieved 4 May 2020.

 Simpson S, Kaufmann MC, Glozman V, Chakrabarti A (May 2020). "Disease X: accelerating the development of medical countermeasures for the next pandemic". The Lancet. Infectious Diseases. 20 (5): e108–15. doi:10.1016/S1473-3099(20)30123-7. ISSN 1474-4457. PMC 7158580. PMID 32197097.

 "Clinical Development Success Rates 2006–2015" (PDF). BIO Industry Analysis. June 2016. Archived (PDF) from the original on 12 September 2019. Retrieved 23 March 2020.

 Blackwell T (20 April 2020). "COVID-19 vaccine researchers say pandemic lockdown placing many serious obstacles to their work". National Post. Archived from the original on 1 November 2020. Retrieved 3 May 2020.

 Chen J (4 May 2020). "Covid-19 has shuttered labs. It could put a generation of researchers at risk". Stat. Archived from the original on 6 May 2020. Retrieved 4 May 2020.

 Diamond MS, Pierson TC (13 May 2020). "The challenges of vaccine development against a new virus during a pandemic". Cell Host and Microbe. 27 (5): 699–703. doi:10.1016/j.chom.2020.04.021. PMC 7219397. PMID 32407708.

 "COVID-19 vaccine development pipeline (Refresh URL to update)". Vaccine Centre, London School of Hygiene and Tropical Medicine. 16 December 2020. Retrieved 18 December 2020.

 "Vaccine Safety – Vaccines". vaccines.gov. US Department of Health and Human Services. Archived from the original on 22 April 2020. Retrieved 13 April 2020.

 "The drug development process". U.S. Food and Drug Administration (FDA). 4 January 2018. Archived from the original on 22 February 2020. Retrieved 12 April 2020.

 Cohen J (19 June 2020). "Pandemic vaccines are about to face the real test". Science. 368 (6497): 1295–96. Bibcode:2020Sci...368.1295C. doi:10.1126/science.368.6497.1295. PMID 32554572.

 "How flu vaccine effectiveness and efficacy are measured". Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, US Department of Health and Human Services. 29 January 2016. Archived from the original on 7 May 2020. Retrieved 6 May 2020.

 "Principles of epidemiology, Section 8: Concepts of disease occurrence". Centers for Disease Control and Prevention, Center for Surveillance, Epidemiology, and Laboratory Services, US Department of Health and Human Services. 18 May 2012. Archived from the original on 6 April 2020. Retrieved 6 May 2020.

 Chen W, Al Kaabi N (18 July 2020). "A Phase III clinical trial for inactivated novel coronavirus pneumonia (COVID-19) vaccine (Vero cells)". Chinese Clinical Trial Registry. Retrieved 15 August 2020.

 "UAE: Ministry of Health announces 86 per cent vaccine efficacy". GulfNews. Retrieved 9 December 2020.

 Cornwell, Alexander (9 December 2020). "UAE says Sinopharm vaccine has 86% efficacy against COVID-19". Reuters. Retrieved 9 December 2020.

 Yang Y. "A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above". ClinicalTrials.gov. Archived from the original on 14 September 2020. Retrieved 15 September 2020.

 "Clinical Trial to Evaluate the Efficacy, Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (COVID-19)". ClinicalTrials.gov. Retrieved 28 September 2020.

 "A Phase III clinical trial for inactivated novel coronavirus pneumonia (COVID-19) vaccine (Vero cells)". www.chictr.org.cn. Chinese Clinical Trial Register (ChiCTR). Retrieved 15 December 2020.

 "Bahrain allows Sinopharm COVID-19 vaccine candidate use in frontline workers". MSN. Reuters. Retrieved 3 November 2020.

 Xia S, Duan K, Zhang Y, Zhao D, et al. (13 August 2020). "Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials". JAMA. 324 (10): 951–960. doi:10.1001/jama.2020.15543. PMC 7426884. PMID 32789505.

 "China Sinopharm's COVID-19 vaccine taken by about 1 million people in emergency use". CNA. Retrieved 22 November 2020.

 Wee, Sui-Lee (9 December 2020). "Chinese Covid-19 Vaccine Gets Key Push, but Doubts Swirl". The New York Times. Retrieved 12 December 2020.

 Dou, Eva; Schemm, Paul (9 December 2020). "Coronavirus vaccine from China's Sinopharm is 86% effective, UAE officials say". Washington Post. ISSN 0190-8286. Retrieved 9 December 2020.

 "Coronavirus: UAE authorises emergency use of vaccine for frontline workers". The National. Retrieved 24 November 2020.

 "Safety and Immunogenicity Study of Inactivated Vaccine for Prevention of SARS-CoV-2 Infection (COVID-19) (Renqiu)". ClinicalTrials.gov (Registry). United States National Library of Medicine. 12 May 2020. NCT04383574. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals (PROFISCOV)". ClinicalTrials.gov (Registry). United States National Library of Medicine. 2 July 2020. NCT04456595. Archived from the original on 11 October 2020. Retrieved 3 August 2020.

 PT. Bio Farma (10 August 2020). "A Phase III, observer-blind, randomized, placebo-controlled study of the efficacy, safety, and immunogenicity of SARS-COV-2 inactivated vaccine in healthy adults aged 18–59 years in Indonesia". Registri Penyakit Indonesia. Retrieved 15 August 2020.

 "Tests show coronavirus vaccine by China's Sinovac is safe, says Brazil's Butantan Institute". Archived from the original on 29 October 2020. Retrieved 29 October 2020.

 "Chile initiates clinical study for COVID-19 vaccine". Archived from the original on 11 October 2020. Retrieved 29 October 2020.

 "Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial For Evaluation of Efficacy and Safety of SARS-CoV-2 Vaccine (Vero Cell), Inactivated". ClinicalTrials.gov. 8 October 2020. Archived from the original on 20 October 2020. Retrieved 22 October 2020.

 Zhang Y, Zeng G, Pan H, Li C, Hu Y, Chu K, et al. (November 2020). "Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial". The Lancet Infectious Diseases. 0. doi:10.1016/S1473-3099(20)30843-4. PMID 33217362. S2CID 227099817.

 Wu, Huizhong (6 December 2020). "China prepares large-scale rollout of domestically-produced coronavirus vaccines". The Globe and Mail. Retrieved 7 December 2020.

 Chinese vaccine expected to arrive in Turkey this week hurriyetdailynews.com. 20 December 2020.

 "Clinical Trial of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Vaccine Against COVID-19". ClinicalTrials.gov. Archived from the original on 12 September 2020. Retrieved 11 September 2020.

 Kumar, Shivani (1 December 2020). "Sputnik-V from Russia arrives in India for clinal trials". Hindustan Times.

 "Clinical trial: 17 volunteers given Russia's Sputnik V Covid-19 vaccine in Pune". The Indian Express. 6 December 2020.

 Logunov DY, Dolzhikova IV, others (2020). "Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia". The Lancet. 396 (10255): 887–97. doi:10.1016/s0140-6736(20)31866-3. ISSN 0140-6736. PMC 7471804. PMID 32896291. S2CID 221472251.

 Burki TK (November 2020). "The Russian vaccine for COVID-19". The Lancet. Respiratory Medicine. 8 (11): e85–e86. doi:10.1016/S2213-2600(20)30402-1. PMID 32896274.

 "A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19". ClinicalTrials.gov (Registry). United States National Library of Medicine. 14 July 2020. NCT04470427. Archived from the original on 11 October 2020. Retrieved 27 July 2020.

 Palca J (27 July 2020). "COVID-19 vaccine candidate heads to widespread testing in U.S." NPR. Archived from the original on 11 October 2020. Retrieved 27 July 2020.

 "Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine". National Institutes of Health (NIH). 15 November 2020.

 National Institute of Allergy and Infectious Diseases (NIAID) (3 December 2020). "Phase I, Open-Label, Dose-Ranging Study of the Safety and Immunogenicity of 2019-nCoV Vaccine (mRNA-1273) in Healthy Adults".

 "Dose-Confirmation Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1273 COVID-19 Vaccine in Adults Aged 18 Years and Older". ClinicalTrials.gov. Retrieved 19 December 2020.

 Widge AT, Rouphael NG, Jackson LA, Anderson EJ, Roberts PC, Makhene M, et al. (3 December 2020). "Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination". New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmc2032195. ISSN 0028-4793.

 Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, et al. (mRNA-1273 Study Group) (July 2020). "An mRNA Vaccine against SARS-CoV-2 – Preliminary Report". New England Journal of Medicine. 383 (20): 1920–1931. doi:10.1056/NEJMoa2022483. PMC 7377258. PMID 32663912. Lay summary.

 Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, et al. (mRNA-1273 Study Group) (July 2020). "An mRNA Vaccine against SARS-CoV-2 – Preliminary Report Supplementary appendix". New England Journal of Medicine. doi:10.1056/NEJMoa2022483. PMID 32663912.

 "EMA receives application for conditional marketing authorisation of Moderna COVID-19 vaccine". European Medicines Agency (EMA) (Press release). 1 December 2020. Retrieved 1 December 2020.

 Kitching C (1 December 2020). "Moderna coronavirus vaccine could get UK approval within two weeks, says expert". Daily Mirror. Retrieved 1 December 2020.

 "Drug and vaccine authorizations for COVID-19: List of applications received". Health Canada, Government of Canada. 9 December 2020. Retrieved 9 December 2020.

 Swissmedic reviews vaccine candidate from Moderna. 13 November 2020.

 Benefits and risks of Covid-19 vaccines: rapid authorisations are possible, but premature vaccinations are not the answer for Switzerland . Retrieved 13 December 2020.

 "Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Adults". ClinicalTrials.gov (Registry). United States National Library of Medicine. 30 April 2020. NCT04368728. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "A Multi-site Phase I/II, 2-Part, Dose-Escalation Trial Investigating the Safety and Immunogenicity of four Prophylactic SARS-CoV-2 RNA Vaccines Against COVID-19 Using Different Dosing Regimens in Healthy Adults". EU Clinical Trials Register (Registry). European Union. 14 April 2020. EudraCT 2020-001038-36. Archived from the original on 22 April 2020. Retrieved 22 April 2020.

 "Pfizer and BioNTech Announce Publication of Results from Landmark Phase 3 Trial of BNT162b2 COVID-19 Vaccine Candidate in The New England Journal of Medicine". Pfizer. Retrieved 11 December 2020 – via Business Wire.

 Lovelace Jr B (18 November 2020). "Pfizer says final data analysis shows Covid vaccine is 95% effective, plans to submit to FDA in days". CNBC.

 "Pfizer and BioNTech Announce Publication of Results from Landmark Phase 3 Trial of BNT162b2 COVID-19 Vaccine Candidate in The New England Journal of Medicine". Pfizer. Retrieved 11 December 2020 – via Business Wire.

 FDA Review of Efficacy and Safety of Pfizer-BioNTech COVID-19 Vaccine Emergency Use Authorization Request. U.S. Food and Drug Administration (FDA) (Report). 10 December 2020. Retrieved 11 December 2020.  This article incorporates text from this source, which is in the public domain.

 Erman, Michael (18 November 2020). "Pfizer ends COVID-19 trial with 95% efficacy, to seek emergency-use authorization". Reuters. Retrieved 18 November 2020.

 Zimmer, Carl (20 November 2020). "2 Companies Say Their Vaccines Are 95% Effective. What Does That Mean? You might assume that 95 out of every 100 people vaccinated will be protected from Covid-19. But that's not how the math works". The New York Times. Retrieved 21 November 2020.

 Tiggle, Nick (9 December 2020). "Covid-19 vaccine: Allergy warning over new jab". BBC News. Retrieved 9 December 2020.

 Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. (October 2020). "Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults". Nature. 586 (7830): 589–593. doi:10.1038/s41586-020-2639-4. PMID 32785213. S2CID 221126922.

 "Information for Healthcare Professionals on Pfizer/BioNTech COVID-19 vaccine". Medicines & Healthcare products Regulatory Agency (MHRA). 8 December 2020. Retrieved 13 December 2020.

 "Conditions of Authorisation for Pfizer/BioNTech COVID-19 vaccine". Medicines & Healthcare products Regulatory Agency (MHRA). 3 December 2020. Retrieved 13 December 2020.

 "Bahrain becomes second country to approve Pfizer COVID-19 vaccine". Al Jazeera. Retrieved 5 December 2020.

 Thomas K (11 December 2020). "F.D.A. Clears Pfizer Vaccine, and Millions of Doses Will Be Shipped Right Away". The New York Times. Retrieved 11 December 2020.

 "FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine" (Press release). U.S. Food and Drug Administration (FDA). 11 December 2020. Retrieved 11 December 2020.  This article incorporates text from this source, which is in the public domain.

 "Pfizer-BioNTech COVID-19 Vaccine EUA Letter of Authorization" (PDF). U.S. Food and Drug Administration (FDA). 11 December 2020.  This article incorporates text from this source, which is in the public domain.

 "Pfizer-BioNTech COVID-19 Vaccine EUA Fact Sheet for Healthcare Providers" (PDF). Pfizer. 11 December 2020.

 "Mexico Approves Pfizer Vaccine for Emergency Use as Covid Surges". Bloomberg. 12 December 2020. Retrieved 12 December 2020.

 "Kuwait authorizes emergency use of Pfizer-BioNTech COVID-19 vaccine". Arab News. 13 December 2020. Retrieved 15 December 2020.

 "Singapore approves use of Pfizer's COVID-19 vaccine". AP NEWS. 14 December 2020. Retrieved 15 December 2020.

 "Jordan approves Pfizer-BioNTech Covid vaccine". France 24. 15 December 2020. Retrieved 15 December 2020.

 "Coronavirus: Saudi Arabia approves Pfizer COVID-19 vaccine for use". Al Arabiya English. 10 December 2020. Retrieved 10 December 2020.

 Zimmer, Carl; Corum, Jonathan; Wee, Sui-Lee (10 June 2020). "Coronavirus Vaccine Tracker". The New York Times. ISSN 0362-4331. Retrieved 12 December 2020.

 "COVID-19 vaccine tracker (Choose vaccines tab, apply filters to view select data)". Milken Institute. 8 December 2020. Retrieved 11 December 2020. Lay summary.

 "AstraZeneca & Serum Institute of India sign licensing deal for 1 million doses of Oxford vaccine". The Economic Times. Retrieved 15 June 2020.

 "Covid-19 vaccine: Serum Institute signs up for 100 million doses of vaccines for India, low and middle-income countries". The Financial Express. 7 August 2020.

 Walsh N, Shelley J, Duwe E, Bonnett W (27 July 2020). "The world's hopes for a coronavirus vaccine may run in these health care workers' veins". CNN. São Paulo. Archived from the original on 3 August 2020. Retrieved 3 August 2020.

 "Investigating a Vaccine Against COVID-19". ClinicalTrials.gov (Registry). United States National Library of Medicine. 26 May 2020. NCT04400838. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "A Phase 2/3 study to determine the efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19". EU Clinical Trials Register (Registry). European Union. 21 April 2020. EudraCT 2020-001228-32. Archived from the original on 5 October 2020. Retrieved 3 August 2020.

 O'Reilly P (26 May 2020). "A Phase III study to investigate a vaccine against COVID-19". ISRCTN (Registry). doi:10.1186/ISRCTN89951424. ISRCTN89951424.

 "A Phase III Randomized, Double-blind, Placebo-controlled Multicenter Study in Adults to Determine the Safety, Efficacy, and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, for the Prevention of COVID-19". ClinicalTrials.gov (Registry). United States National Library of Medicine. 12 May 2020. NCT04383574. Archived from the original on 23 August 2020. Retrieved 26 August 2020.

 "Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK - The Lancet". Retrieved 9 December 2020.

 "Trial of Oxford COVID-19 vaccine starts in Brazil". Jenner Institute. Archived from the original on 9 September 2020. Retrieved 26 August 2020.

 "Oxford COVID-19 vaccine final trials will be held in these 17 hospitals in India". mint. 19 August 2020.

 Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, et al. (July 2020). "Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial". Lancet. 396 (10249): 467–78. doi:10.1016/S0140-6736(20)31604-4. PMC 7445431. PMID 32702298. Lay summary.

 "After Pfizer, Pune's Serum Institute seeks nod for emergency use of its Oxford vaccine". The Indian Express. 7 December 2020.

 Ebrard, Marcelo. "Informe de avance sobre vacunas al 15 de diciembre de 2020". Retrieved 17 December 2020.

 Swissmedic starts rolling review of a COVID-19 vaccine. 6 October 2020.

 "Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) Against COVID-19". ClinicalTrials.gov (Registry). United States National Library of Medicine. 13 November 2020. NCT04540419. Retrieved 17 November 2020.

 "The National Research Council of Canada and CanSino Biologics Inc. announce collaboration to advance vaccine against COVID-19". National Research Council, Government of Canada. 12 May 2020. Archived from the original on 22 May 2020. Retrieved 22 May 2020.

 Lazcano, Patricio (15 November 2020). "Así funcionan las cuatro vacunas que se probarán en Chile". La Tercera. Retrieved 15 December 2020.

 Martinez, Ana Isabel (3 November 2020). "CanSino Biologics delivers COVID-19 vaccine to Mexico for late-stage trial". Reuters. Retrieved 4 November 2020.

 Ng, Eric (28 October 2020). "China's CanSino trials Covid-19 vaccine in 'high disease burden' nations". South China Morning Post. Retrieved 4 November 2020.

 Nafisa, Eltahir (9 August 2020). "CanSino to start Phase III trial of COVID-19 vaccine in Saudi". Reuters. Retrieved 4 November 2020.

 Gou J. "Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above". ClinicalTrials.gov. Archived from the original on 18 September 2020. Retrieved 17 September 2020.

 Zhu F, Guan X, Li Y, Huang J, Jiang T, Hou L, et al. (July 2020). "Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial". Lancet. 396 (10249): 479–88. doi:10.1016/s0140-6736(20)31605-6. ISSN 0140-6736. PMID 32702299. Lay summary.

 Ebrard, Marcelo. "Informe de avance sobre vacunas al 15 de diciembre de 2020". Retrieved 17 December 2020.

 "A Study of Ad26.COV2.S in Adults". ClinicalTrials.gov. 4 August 2020. Archived from the original on 16 September 2020. Retrieved 23 August 2020.

 Sadoff J, Le Gars M, Shukarev G, Heerwegh D, Truyers C, de Groot AM, Stoop J, Tete S, Van Damme W, Leroux-Roels I, Berghmans P (25 September 2020). Safety and immunogenicity of the Ad26.COV2.S COVID-19 vaccine candidate: interim results of a phase 1/2a, double-blind, randomized, placebo-controlled trial. doi:10.1101/2020.09.23.20199604. S2CID 221882008. Archived from the original on 1 November 2020. Retrieved 27 September 2020.

 "A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants". ClinicalTrials.gov. US National Library of Medicine. Archived from the original on 26 September 2020.

 Virginia Hughes, Katie Thomas, Carl Zimmer, Katherine J. Wu (13 October 2020). "Johnson & Johnson pauses its coronavirus vaccine trial because of a volunteer's 'unexplained illness.'". The New York Times. Archived from the original on 24 October 2020. Retrieved 25 October 2020.

 Burton TM, Loftus P (23 October 2020). "Pivotal Studies of Covid-19 Vaccines From AstraZeneca, J&J Resuming". The Wall Street Journal. Archived from the original on 26 October 2020. Retrieved 26 October 2020.

 Johnson CY (24 October 2020). "Johnson & Johnson, AstraZeneca coronavirus vaccine trials set to resume". The Washington Post. Archived from the original on 26 October 2020. Retrieved 26 October 2020.

 "EMA starts rolling review of Janssen's COVID-19 vaccine Ad26.COV2.S". European Medicines Agency (EMA) (Press release). 1 December 2020. Retrieved 1 December 2020.

 "Johnson & Johnson the first to apply for Covid-19 vaccine registration as South Africa starts review process" msn.com. 17 December 2020.

 "Evaluation of the Safety and Immunogenicity of a SARS-CoV-2 rS (COVID-19) Nanoparticle Vaccine With/Without Matrix-M Adjuvant". ClinicalTrials.gov (Registry). United States National Library of Medicine. 30 April 2020. NCT04368988. Archived from the original on 14 July 2020. Retrieved 14 July 2020.

 "A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom". ClinicalTrials.gov. Retrieved 22 November 2020.

 Yengkhom, Sumati (23 November 2020). "Three Kolkata institutes queue up for corona vaccine trials | Kolkata News - Times of India". The Times of India.

 Keech C, Albert G, Cho I, Robertson A, Reed P, Neal S, et al. (September 2020). "Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine". The New England Journal of Medicine. 383 (24): 2320–2332. doi:10.1056/NEJMoa2026920. PMC 7494251. PMID 32877576.

 Ebrard, Marcelo. "Informe de avance sobre vacunas al 15 de diciembre de 2020". Retrieved 17 December 2020.

 "An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers". ClinicalTrials.gov (Registry). NCT04641481. Retrieved 26 November 2020.

 Ella, Raches; Mohan, Krishna; Jogdand, Harsh; Prasad, Sai; Reddy, Siddharth; Sarangi, Vamshi Krishna; Ganneru, Brunda; Sapkal, Gajanan; Yadav, Pragya; Panda, Samiran; Gupta, Nivedita; Reddy, Prabhakar; Verma, Savita; Rai, Sanjay; Singh, Chandramani; Redkar, Sagar; Gillurkar, Chandra Sekhar; Kushwaha, Jitendra Singh; Rao, Venkat; Mohapatra, Satyajit; Guleria, Randeep; Ella, Krishna; Bhargava, Balram (15 December 2020). "Safety and immunogenicity trial of an inactivated SARS-CoV-2 vaccine-BBV152: a phase 1, double-blind, randomised control trial". medRxiv preprint. doi:10.1101/2020.12.11.20210419.

 "Whole-Virion Inactivated SARS-CoV-2 Vaccine (BBV152) for COVID-19 in Healthy Volunteers". ClinicalTrials.gov (Registry). NCT04471519.

 Dwivedi, Sukirti; Dey, Stela (8 December 2020). "Bharat Biotech Seeks Emergency Use Approval For Covaxin". NDTV.com.

 "GSK, Medicago launch phase 2/3 clinical trials of plant-derived COVID-19 vaccine". PMLive. 13 November 2020. Retrieved 16 November 2020.

 Chander V (14 July 2020). "Canada's Medicago begins human trials of plant-based COVID-19 vaccine". National Post. Reuters. Archived from the original on 1 November 2020. Retrieved 14 July 2020.

 Medicago (18 November 2020). "Randomized, Observer-Blind, Placebo-Controlled, Phase 2/3 Study to Assess the Safety, Efficacy, and Immunogenicity of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults 18 Years of Age or Older".

 Ward BJ, Gobeil P, Séguin A, Atkins J, Boulay I, Charbonneau P, et al. (November 2020). "Phase 1 trial of a Candidate Recombinant Virus-Like Particle Vaccine for Covid-19 Disease Produced in Plants". MedRxiv: 2020.11.04.20226282. doi:10.1101/2020.11.04.20226282. S2CID 226255762.

 Medicago (21 October 2020). "A Randomized, Partially-Blinded, Dose-Ranging Phase 1 Study to Assess the Safety, Tolerability, and Immunogenicity of a Recombinant Coronavirus-Like Particle COVID 19 Vaccine in Adults 18–55 Years of Age".

 "Phase I Clinical Study of Recombinant Novel Coronavirus Vaccine". ClinicalTrials.gov (Registry). United States National Library of Medicine. 24 June 2020. NCT04445194. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "A Randomized, Blinded, Placebo-controlled Trial to Evaluate the Immunogenicity and Safety of a Recombinant New Coronavirus Vaccine (CHO Cell) With Different Doses and Different Immunization Procedures in Healthy People Aged 18 to 59 Years". ClinicalTrials.gov (Registry). United States National Library of Medicine. 10 July 2020. NCT04466085. Archived from the original on 28 July 2020. Retrieved 26 August 2020.

 "COVID-19: A Phase 2b/3, Randomized, Observer-Blinded, Placebo Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older". EU Clinical Trials Register. 19 November 2020. 2020-003998-22. Retrieved 19 December 2020.

 "A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults". ClinicalTrials.gov. 26 June 2020. NCT04449276. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "A Dose-Confirmation Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults". ClinicalTrials.gov. 17 August 2020. NCT04515147. Archived from the original on 23 August 2020. Retrieved 28 August 2020.

 "Safety, Tolerability and Immunogenicity of INO-4800 for COVID-19 in Healthy Volunteers". ClinicalTrials.gov (Registry). United States National Library of Medicine. 7 April 2020. NCT04336410. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "IVI, INOVIO, and KNIH to partner with CEPI in a Phase I/II clinical trial of INOVIO's COVID-19 DNA vaccine in South Korea". International Vaccine Institute. 16 April 2020. Retrieved 23 April 2020.

 "Study of the Safety, Reactogenicity and Immunogenicity of "EpiVacCorona" Vaccine for the Prevention of COVID-19 (EpiVacCorona)". ClinicalTrials.gov (Registry). United States National Library of Medicine. 22 September 2020. NCT04368988. Retrieved 16 November 2020.

 "Safety and Immunogenicity Study of an Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19". ClinicalTrials.gov (Registry). United States National Library of Medicine. 2 June 2020. NCT04412538. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "Study of COVID-19 DNA Vaccine (AG0301-COVID19)". ClinicalTrials.gov (Registry). United States National Library of Medicine. 9 July 2020. NCT04463472. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "About AnGes – Introduction". AnGes, Inc. Archived from the original on 11 October 2020. Retrieved 1 August 2020.

 "CTI and Arcturus Therapeutics Announce Initiation of Dosing of COVID-19 STARR™ mRNA Vaccine Candidate, LUNAR-COV19 (ARCT-021) in a Phase 1/2 study". UK BioIndustry Association. 13 August 2020. Archived from the original on 11 October 2020. Retrieved 23 August 2020.

 "Ascending Dose Study of Investigational SARS-CoV-2 Vaccine ARCT-021 in Healthy Adult Subjects". clinicaltrials.gov. Archived from the original on 11 October 2020. Retrieved 23 August 2020.

 "Safety and Immunity of Covid-19 aAPC Vaccine". ClinicalTrials.gov (Registry). United States National Library of Medicine. 9 March 2020. NCT04299724. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "About Us". Shenzhen Genoimmune Medical Institute. Archived from the original on 11 October 2020. Retrieved 1 August 2020.

 "Immunity and Safety of Covid-19 Synthetic Minigene Vaccine". ClinicalTrials.gov (Registry). United States National Library of Medicine. 19 February 2020. NCT04276896. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 Ward D, McCormack S (22 May 2020). "Clinical trial to assess the safety of a coronavirus vaccine in healthy men and women". ISRCTN (Registry). doi:10.1186/ISRCTN17072692. ISRCTN17072692.

 "A prospective, randomized, adaptive, phase I/II clinical study to evaluate the safety and immunogenicity of Novel Corona Virus -2019-nCov vaccine candidate of M/s Cadila Healthcare Limited by intradermal route in healthy subjects". ctri.nic.in (Registry). Clinical Trials Registry India. 15 December 2020. CTRI/2020/07/026352. Archived from the original on 22 November 2020.

 Rawat, Kajal; Kumari, Puja; Saha, Lekha (24 November 2020). "COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies". European Journal of Pharmacology: 173751. doi:10.1016/j.ejphar.2020.173751. ISSN 1879-0712. PMC 7685956. PMID 33245898.

 Thacker, Teena. "Zydus Cadila to test ZyCoV-D on 30,000 patients in Phase-3 trials". The Economic Times. Retrieved 16 December 2020.

 "Safety and Immunogenicity Study of GX-19, a COVID-19 Preventive DNA Vaccine in Healthy Adults". ClinicalTrials.gov (Registry). United States National Library of Medicine. 24 June 2020. NCT04445389. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "S. Korea's Genexine begins human trial of coronavirus vaccine". Reuters. 19 June 2020. Archived from the original on 11 October 2020. Retrieved 25 June 2020.

 "Genexine consortium's Covid-19 vaccine acquires approval for clinical trails in Korea". 11 June 2020. Retrieved 1 August 2020.

 "SCB-2019 as COVID-19 Vaccine". ClinicalTrials.gov (Registry). United States National Library of Medicine. 28 May 2020. NCT04405908. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "Clover Biopharmaceuticals starts Phase I Covid-19 vaccine trial". Clinical Trials Arena. 20 June 2020. Archived from the original on 11 October 2020. Retrieved 25 June 2020.

 "About Us". Clover Biopharmaceuticals. Archived from the original on 11 October 2020. Retrieved 1 August 2020.

 "Monovalent Recombinant COVID19 Vaccine (COVAX19)". ClinicalTrials.gov (Registry). United States National Library of Medicine. 1 July 2020. NCT04453852. Archived from the original on 11 October 2020. Retrieved 14 July 2020.

 "Vaxine". Archived from the original on 11 October 2020. Retrieved 1 August 2020.

 "A Phase I clinical trial to evaluate the safety, tolerance and preliminary immunogenicity of different doses of a SARS-CoV-2 mRNA vaccine in population aged 18–59 years and 60 years and above". Chinese Clinical Trial Register (Registry). 24 June 2020. ChiCTR2000034112. Archived from the original on 11 October 2020. Retrieved 6 July 2020.

 "Company introduction". Walvax Biotechnology. Archived from the original on 11 October 2020. Retrieved 1 August 2020.

 "A Study on the Safety, Tolerability and Immune Response of SARS-CoV-2 Sclamp (COVID-19) Vaccine in Healthy Adults". ClinicalTrials.gov (Registry). United States National Library of Medicine. 3 August 2020. NCT04495933. Archived from the original on 11 October 2020. Retrieved 4 August 2020.

 "UQ-CSL V451 Vaccine". www.precisionvaccinations.com. Retrieved 11 December 2020.

 "Public statement for collaboration on COVID-19 vaccine development". World Health Organization. 13 April 2020. Archived from the original on 20 April 2020. Retrieved 20 April 2020.

 Gouglas D, Thanh Le T, Henderson K, Kaloudis A, Danielsen T, Hammersland NC, Robinson JM, Heaton PM, Røttingen JA (December 2018). "Estimating the cost of vaccine development against epidemic infectious diseases: a cost minimisation study". Lancet Global Health. 6 (12): e1386–96. doi:10.1016/S2214-109X(18)30346-2. PMC 7164811. PMID 30342925.

 Strovel J, Sittampalam S, Coussens NP, Hughes M, Inglese J, Kurtz A, et al. (1 July 2016). "Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start-up Companies". Assay Guidance Manual. Eli Lilly & Company and the National Center for Advancing Translational Sciences. PMID 22553881. Archived from the original on 19 April 2020. Retrieved 21 April 2020.

 DiMasi JA, Grabowski HG, Hansen RW (May 2016). "Innovation in the pharmaceutical industry: New estimates of R&D costs". Journal of Health Economics. 47: 20–33. doi:10.1016/j.jhealeco.2016.01.012. hdl:10161/12742. PMID 26928437.

 "Bacille Calmette-Guérin (BCG) vaccination and COVID-19". World Health Organization (WHO). 12 April 2020. Archived from the original on 30 April 2020. Retrieved 1 May 2020.

 Takahashi, Harutaka (4 November 2020). "Role of latent tuberculosis infections in reduced COVID-19 mortality: Evidence from an instrumental variable method analysis". Medical Hypotheses. 144: 110214. doi:10.1016/j.mehy.2020.110214. PMC 7448767. PMID 33254521.

 Tregoning JS, Russell RF, Kinnear E (25 January 2018). "Adjuvanted influenza vaccines". Human Vaccines and Immunotherapeutics. 14 (3): 550–64. doi:10.1080/21645515.2017.1415684. ISSN 2164-5515. PMC 5861793. PMID 29232151.

 Wang J, Peng Y, Xu H, Cui Z, Williams RO (5 August 2020). "The COVID-19 vaccine race: Challenges and opportunities in vaccine formulation". AAPS PharmSciTech. 21 (6): 225. doi:10.1208/s12249-020-01744-7. ISSN 1530-9932. PMC 7405756. PMID 32761294.

 Thorp HH (27 March 2020). "Underpromise, overdeliver". Science. 367 (6485): 1405. Bibcode:2020Sci...367.1405T. doi:10.1126/science.abb8492. PMID 32205459.

 Iwasaki A, Yang Y (21 April 2020). "The potential danger of suboptimal antibody responses in COVID-19". Nature Reviews Immunology. 20 (6): 339–41. doi:10.1038/s41577-020-0321-6. ISSN 1474-1733. PMC 7187142. PMID 32317716.

 Wiedermann U, Garner-Spitzer E, Wagner A (2016). "Primary vaccine failure to routine vaccines: Why and what to do?". Human Vaccines and Immunotherapeutics. 12 (1): 239–43. doi:10.1080/21645515.2015.1093263. ISSN 2164-554X. PMC 4962729. PMID 26836329.

 Zumla A, Hui DS, Perlman S (11 September 2015). "Middle East respiratory syndrome". Lancet. 386 (9997): 995–1007. doi:10.1016/S0140-6736(15)60454-8. PMC 4721578. PMID 26049252.

 Garcia de Jesus E (26 May 2020). "Is the coronavirus mutating? Yes. But here's why you don't need to panic". Science News. Archived from the original on 21 June 2020. Retrieved 21 June 2020.

 Grove Krause, Tyra. "Mutationer i minkvirus" (in Danish). Statens Serum Institut. Retrieved 6 November 2020.

 Dubé E, Laberge C, Guay M, Bramadat P, Roy R, Bettinger J (1 August 2013). "Vaccine hesitancy: an overview". Human Vaccines and Immunotherapeutics. 9 (8): 1763–73. doi:10.4161/hv.24657. ISSN 2164-554X. PMC 3906279. PMID 23584253.

 Howard J, Stracqualursi V (18 June 2020). "Fauci warns of 'anti-science bias' being a problem in US". CNN. Archived from the original on 21 June 2020. Retrieved 21 June 2020.

 Winter SS, Page-Reeves JM, Page KA, Haozous E, Solares A, Nicole Cordova C, Larson RS (28 May 2018). "Inclusion of special populations in clinical research: important considerations and guidelines". Journal of Clinical and Translational Research (Review). 4 (1): 56–69. ISSN 2382-6533. PMC 6410628. PMID 30873495.

 "Ten health issues WHO will tackle this year". World Health Organization. 2019. Archived from the original on 11 November 2019. Retrieved 26 May 2020.

 Malik AA, McFadden SM, Elharake J, Omer SB (2020). "Determinants of COVID-19 vaccine acceptance in the US". EClinicalMedicine, the Lancet. 26: 100495. doi:10.1016/j.eclinm.2020.100495. ISSN 2589-5370. PMC 7423333. PMID 32838242.

 Linda Thunström, Madison Ashworth, David Finnoff, and Stephen C. Newbold. 2020. Hesitancy towards a COVID‑19 vaccine and prospects for herd immunity. Covid Economics 35 Archived 11 October 2020 at the Wayback Machine: 7 July 2020

 Beard, David (3 December 2020). "Poll shows 61 percent of Americans likely to take COVID-19 vaccine". National Geographic. Retrieved 12 December 2020.

 Gates B (23 April 2020). "The first modern pandemic: The scientific advances we need to stop COVID-19". The Gates Notes. Archived from the original on 13 May 2020. Retrieved 6 May 2020.

 Blanchfield M (30 April 2020). "Global philanthropists, experts call for COVID-19 vaccine distribution plan". The Toronto Star. Archived from the original on 7 May 2020. Retrieved 6 May 2020.

 Stevis-Gridneff M, Jakes L (4 May 2020). "World Leaders Join to Pledge $8 Billion for Vaccine as U.S. Goes It Alone". The New York Times. ISSN 0362-4331. Archived from the original on 13 May 2020. Retrieved 10 May 2020.

 Jennings, Katie (17 November 2020). "How Much Will A Covid-19 Vaccine Cost?". Forbes. Retrieved 6 December 2020.

 "European vaccine prices revealed in Belgian Twitter blunder". The Brussels Times. 18 December 2020.

 Bossaert, Jeroen (17 December 2020). "Zoveel gaan we betalen voor de coronavaccins: staatssecretaris zet confidentiële prijzen per ongeluk online". Het Laatste Nieuws. Retrieved 18 December 2020.

 "Pfizer-BioNTech COVID-19 Vaccine Vaccination Storage & Dry Ice Safety Handling". Pfizer. Retrieved 17 December 2020.

 "7 looming questions about the rollout of a Covid-19 vaccine". Stat. 9 October 2020. Archived from the original on 10 October 2020. Retrieved 10 October 2020.

 https://www.phillyvoice.com/noreaster-delay-pfizer-vaccine-deliveries-east-coast/

 Eyal N, Lipsitch M, Smith PG (31 March 2020). "Human challenge studies to accelerate coronavirus vaccine licensure". The Journal of Infectious Diseases. 221 (11): 1752–56. doi:10.1093/infdis/jiaa152. PMC 7184325. PMID 32232474.

 Callaway E (April 2020). "Should scientists infect healthy people with the coronavirus to test vaccines?". Nature. 580 (7801): 17. Bibcode:2020Natur.580...17C. doi:10.1038/d41586-020-00927-3. PMID 32218549.

 Boodman E (13 March 2020). "Coronavirus vaccine clinical trial starting without usual animal data". Stat. Archived from the original on 17 April 2020. Retrieved 19 April 2020.

 Cohen J (31 March 2020). "Speed coronavirus vaccine testing by deliberately infecting volunteers? Not so fast, some scientists warn". Science. doi:10.1126/science.abc0006.

 Callaway E (20 October 2020). "Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials". Nature. 586 (7831): 651–652. doi:10.1038/d41586-020-02821-4. PMID 33082550. S2CID 224823112.

 Walker P, Whittaker C, Watson O, Baguelin M, Ainslie K, Bhatia S, et al. (26 March 2020). The global impact of COVID-19 and strategies for mitigation and suppression (Report). Imperial College COVID-19 Response Team. doi:10.25561/77735. hdl:10044/1/77735.

 "Key criteria for the ethical acceptability of COVID-19 human challenge studies" (PDF). World Health Organization. 6 May 2020. Archived (PDF) from the original on 8 May 2020. Retrieved 12 May 2020.

 "WHO publishes Emergency Use Listing procedure and roadmap to make new medical products more readily available during health emergencies". World Health Organization. 9 January 2020. Archived from the original on 29 September 2020. Retrieved 23 August 2020.

 "Vaccines: The Emergency Authorisation Procedure". European Medicines Agency. 2020. Archived from the original on 24 September 2020. Retrieved 21 August 2020.

 Byrne, Jane (19 October 2020). "Moderna COVID-19 vaccine under rolling review process in Canada, EU". BioPharma-Reporter.com, William Reed Business Media Ltd. Retrieved 25 November 2020.

 Dangerfield, Katie (20 November 2020). "Pfizer files for emergency use of coronavirus vaccine in U.S. – what about in Canada?". Global News. Retrieved 25 November 2020.

 "WHO 'backed China's emergency use' of experimental Covid-19 vaccines". South China Morning Post. 25 September 2020. Archived from the original on 26 September 2020. Retrieved 26 September 2020.

 Kramer AE (19 September 2020). "Russia Is Slow to Administer Virus Vaccine Despite Kremlin's Approval". The New York Times. ISSN 0362-4331. Archived from the original on 27 September 2020. Retrieved 28 September 2020.

 "Coronavirus: UAE authorises emergency use of vaccine for frontline workers". The National. Retrieved 18 November 2020.

 Barrington L (3 November 2020). "Bahrain latest country to vaccinate frontline workers with COVID-19 shot". Reuters. Retrieved 18 November 2020.

 "Emergency Use Authorization for Vaccines Explained". U.S. Food and Drug Administration. 20 November 2020. Retrieved 20 November 2020.  This article incorporates text from this source, which is in the public domain.

 "FDA may be risk-averse to grant emergency use for a Covid-19 vaccine; political pressure and hazy EUA standards are factors". ClinicalTrials Arena, Verdict Media, Ltd. 2 July 2020. Archived from the original on 22 July 2020. Retrieved 22 August 2020.

 Hoffman J (18 July 2020). "Mistrust of a coronavirus vaccine could imperil widespread immunity". The New York Times. Archived from the original on 27 September 2020. Retrieved 23 August 2020.

 "Biopharma leaders unite to stand with science". Sanofi (Press release). 8 September 2020. Archived from the original on 29 September 2020. Retrieved 28 September 2020.

 "Pfizer and BioNTech to Submit Emergency Use Authorization Request Today to the U.S. FDA for COVID-19 Vaccine". Pfizer (Press release). 20 November 2020. Retrieved 20 November 2020.

 Park A (20 November 2020). "Exclusive: Pfizer CEO Discusses Submitting the First COVID-19 Vaccine Clearance Request to the FDA". Time. Retrieved 20 November 2020.

 "Information for Healthcare Professionals on Pfizer/BioNTech COVID-19 vaccine". Medicines and Healthcare products Regulatory Agency (MHRA). 8 December 2020. Retrieved 19 December 2020.

 "Conditions of Authorisation for Pfizer/BioNTech COVID-19 vaccine". Medicines and Healthcare products Regulatory Agency (MHRA). 3 December 2020. Retrieved 19 December 2020.

 Mueller, Benjamin (2 December 2020). "U.K. Approves Pfizer Coronavirus Vaccine, a First in the West". The New York Times. Retrieved 2 December 2020.

 Roberts, Michelle (2 December 2020). "Covid Pfizer vaccine approved for use next week in UK". BBC. Retrieved 2 December 2020.

 "Covid-19 vaccine: Margaret Keenan 'so privileged' to get first jab". BBC News. 8 December 2020. Retrieved 8 December 2020.

 Mueller, Benjamin (8 December 2020). "As U.K. Begins Vaccinations, a Glimpse of Life After Covid". The New York Times. The New York Times Company. Retrieved 20 December 2020.

 "Covid: Russia begins vaccinations in Moscow". BBC News Online. 5 December 2020.

 Oliver SE, Gargano JW, Marin M, Wallace M, Curran KG, Chamberland M, et al. (December 2020). "The Advisory Committee on Immunization Practices' Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine - United States, December 2020" (PDF). MMWR Morb Mortal Wkly Rep. 69 (50): 1922–24. doi:10.15585/mmwr.mm6950e2. PMID 33332292.

 "Moderna Applies for Emergency F.D.A. Approval for Its Coronavirus Vaccine". The New York Times. 30 November 2020. Retrieved 30 November 2020.

 "Moderna Announces Primary Efficacy Analysis in Phase 3 COVE Study for Its COVID-19 Vaccine Candidate and Filing Today with U.S. FDA for Emergency Use Authorization". Moderna, Inc. (Press release). 30 November 2020. Retrieved 30 November 2020.

 "COVAX: Working for global equitable access to COVID-19 vaccines". World Health Organization. 2020. Retrieved 18 December 2020.

 "COVAX announces additional deals to access promising COVID-19 vaccine candidates; plans global rollout starting Q1 2021". World Health Organization. 18 December 2020. Retrieved 18 December 2020.

 Weintraub R, Yadav P, Berkley S (2 April 2020). "A COVID-19 vaccine will need equitable, global distribution". Harvard Business Review. ISSN 0017-8012. Archived from the original on 9 June 2020. Retrieved 9 June 2020.

 Bollyky TJ, Gostin LO, Hamburg MA (7 May 2020). "The equitable distribution of COVID-19 therapeutics and vaccines". JAMA. 323 (24): 2462–63. doi:10.1001/jama.2020.6641. PMID 32379268.

 Huneycutt B, Lurie N, Rotenberg S, Wilder R, Hatchett R (24 February 2020). "Finding equipoise: CEPI revises its equitable access policy". Vaccine. 38 (9): 2144–48. doi:10.1016/j.vaccine.2019.12.055. PMC 7130943. PMID 32005536.

 "COVID-19 pandemic reveals the risks of relying on private sector for life-saving vaccines, says expert". CBC Radio. 8 May 2020. Archived from the original on 13 May 2020. Retrieved 8 June 2020.

 "Vaccine for COVID-19". The Center for Artistic Activism. 22 March 2020. Archived from the original on 9 June 2020. Retrieved 8 June 2020.

 "UAEM response to COVID-19". Universities Allied for Essential Medicines. 2020. Archived from the original on 21 April 2020. Retrieved 9 June 2020.

 Ferrucci A. (5 May 2020). "More than 100 scientists call for Covid 19 vaccines to be in the public domain" Archived 14 August 2020 at the Wayback Machine. edc.online.org. Retrieved 21 July 2020.

 Ahmed DD (4 June 2020). "Oxford, AstraZeneca COVID-19 deal reinforces 'vaccine sovereignty'". Stat. Archived from the original on 12 June 2020. Retrieved 8 June 2020.

 Aakash B, Faulconbridge G, Holton K (22 May 2020). "U.S. secures 300 million doses of potential AstraZeneca COVID-19 vaccine". The Guardian. Reuters. Archived from the original on 10 June 2020. Retrieved 10 June 2020.

 Paton J, Griffin R, Koons C. "U.S. likely to get Sanofi vaccine first if it succeeds". Bloomberg. Archived from the original on 8 June 2020. Retrieved 8 June 2020.

 Gretler C (18 May 2020). "China pledges to make its coronavirus vaccine a 'public good'". The National Post. Bloomberg. Archived from the original on 1 November 2020. Retrieved 9 June 2020.

 Cohen, Jon (11 December 2020). "China's vaccine gambit". Science. 370 (6522): 1263–1267. doi:10.1126/science.370.6522.1263. ISSN 0036-8075. PMID 33303601.

 Ng, Abigail (30 November 2020). "China's vaccines may have 'appeal' in developing countries, economist says". CNBC. Retrieved 12 December 2020.

 Blankenship K (4 June 2020). "AstraZeneca unveils massive $750M deal in effort to produce billions of COVID-19 shots". FiercePharma. Archived from the original on 10 June 2020. Retrieved 8 June 2020.

 Callaway, Ewen (27 August 2020). "The unequal scramble for coronavirus vaccines – by the numbers". Nature. 584 (7822): 506–07. Bibcode:2020Natur.584..506C. doi:10.1038/d41586-020-02450-x. PMID 32839593. S2CID 221285160.

 Khamsi R (9 April 2020). "If a coronavirus vaccine arrives, can the world make enough?". Nature. 580 (7805): 578–80. Bibcode:2020Natur.580..578K. doi:10.1038/d41586-020-01063-8. PMID 32273621.

 "Principles and considerations for adding a vaccine to a national immunization programme" (PDF). World Health Organization. 1 April 2014. Archived (PDF) from the original on 29 September 2020. Retrieved 17 August 2020.

 Wijnans, Leonoor; Voordouw, Bettie (11 December 2015). "A review of the changes to the licensing of influenza vaccines in Europe". Influenza and Other Respiratory Viruses. 10 (1): 2–8. doi:10.1111/irv.12351. ISSN 1750-2640. PMC 4687503. PMID 26439108.

 Offit, Paul A. (2020). "Making vaccines: Licensure, recommendations and requirements". Children's Hospital of Philadelphia. Archived from the original on 8 September 2020. Retrieved 20 August 2020.

 Toner E, Barnill A, Krubiner C, others (19 August 2020). "Interim Framework for COVID-19 Vaccine Allocation and Distribution in the United States" (PDF). Baltimore, MD: Johns Hopkins University Center for Health Security. Archived (PDF) from the original on 22 August 2020. Retrieved 24 August 2020.

 "TGA grants provisional determination for COVID-19 vaccine". Therapeutic Goods Administration (TGA). 9 October 2020. Archived from the original on 29 October 2020. Retrieved 25 October 2020.

 "TGA grants second provisional determination for a COVID-19 vaccine". Therapeutic Goods Administration (TGA). 14 October 2020. Archived from the original on 28 October 2020. Retrieved 25 October 2020.

 "TGA grants third provisional determination for a COVID-19 vaccine". Therapeutic Goods Administration (TGA). 16 November 2020. Retrieved 19 December 2020.

 "EMA starts first rolling review of a COVID-19 vaccine in the EU". European Medicines Agency (EMA) (Press release). 1 October 2020. Archived from the original on 1 October 2020. Retrieved 1 October 2020.

 "COVID-19 vaccines: key facts". European Medicines Agency (EMA). 14 September 2020. Archived from the original on 7 October 2020. Retrieved 1 October 2020.

 "EMA starts second rolling review of a COVID-19 vaccine". European Medicines Agency (EMA) (Press release). 5 October 2020. Archived from the original on 6 October 2020. Retrieved 6 October 2020.

 "EMA publishes safety monitoring plan and guidance on risk management planning for COVID-19 vaccines". European Medicines Agency (EMA) (Press release). 13 November 2020. Retrieved 13 November 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

 "EMA considerations on COVID-19 vaccine approval". European Medicines Agency (EMA). 19 November 2020. Retrieved 19 November 2020.

 "EMA starts rolling review of mRNA COVID-19 vaccine by Moderna Biotech Spain, S.L." European Medicines Agency (EMA) (Press release). 16 November 2020. Retrieved 16 November 2020.

 "EMA receives application for conditional marketing authorisation of COVID-19 mRNA vaccine BNT162b2". European Medicines Agency (EMA) (Press release). 1 December 2020. Retrieved 1 December 2020.

 "Update on assessment of the BioNTech and Pfizer BNT162b2 vaccine marketing authorisation application". European Medicines Agency (EMA) (Press release). 15 December 2020. Retrieved 15 December 2020.

 "Update on assessment of marketing authorisation application for Moderna's mRNA-1273 COVID-19 vaccine". European Medicines Agency (EMA) (Press release). 17 December 2020. Retrieved 17 December 2020.

 "Vaccine product approval process". US Food and Drug Administration. 30 January 2020. Archived from the original on 27 September 2020. Retrieved 17 August 2020.

 Dooling K, McClung N, Chamberland M, Marin M, Wallace M, Bell BP, et al. (December 2020). "The Advisory Committee on Immunization Practices' Interim Recommendation for Allocating Initial Supplies of COVID-19 Vaccine - United States, 2020" (PDF). MMWR Morb Mortal Wkly Rep. 69 (49): 1857–9. doi:10.15585/mmwr.mm6949e1. PMID 33301429.

 Sun LH, Stanley-Becker I. "Health-care workers and nursing home residents should be the first to get coronavirus vaccines, CDC advisory group says". The Washington Post. Retrieved 3 December 2020.

 Cohen J (4 June 2020). "Top U.S. scientists left out of White House selection of COVID-19 vaccine short list". Science. doi:10.1126/science.abd1719. ISSN 0036-8075.

 "How the massive plan to deliver the COVID-19 vaccine could make history – and leverage blockchain like never before". World Economic Forum. 17 July 2020. Archived from the original on 16 September 2020. Retrieved 16 September 2020.

 Brendan Murray and Riley Griffin (24 July 2020). "The world's supply chain isn't ready for a Covid-19 vaccine". Bloomberg World. Archived from the original on 28 August 2020. Retrieved 13 September 2020.

 Kominers SD, Tabarrok A (18 August 2020). "Vaccines use bizarre stuff. We need a supply chain now". Bloomberg Business. Archived from the original on 29 August 2020. Retrieved 13 September 2020.

 "The time to prepare for COVID-19 vaccine transport is now". UNICEF. 10 September 2020. Archived from the original on 13 September 2020. Retrieved 13 September 2020.

 Desai D (10 September 2020). "Transporting one single dose of COVID-19 vaccine could take up to 8,000 jumbo planes, says aviation body". National Post. Retrieved 13 September 2020. The IATA estimated that 8,000 747 cargo planes, at minimum, would be needed to transport a single dose of the vaccine worldwide, but more equipment could be required as administering the vaccine might mean several doses. Vaccines would also have to be stored at a temperature range between two and eight degrees Celsius, which could rule out the use of some types of planes.

 Quelch, Rich (14 August 2020). "COVID-19 vaccine delivery – overcoming the supply chain challenges". PharmiWeb.com. Retrieved 13 September 2020. Delivering a new vaccine for COVID-19 worldwide will be one of the greatest challenges faced by modern pharma. The difficulties are intensified by pre-existing shortcomings in the supply chain.

 Seidman, Gabriel; Atun, Rifat (2017). "Do changes to supply chains and procurement processes yield cost savings and improve availability of pharmaceuticals, vaccines or health products? A systematic review of evidence from low-income and middle-income countries". BMJ Global Health. 2 (2): e000243. doi:10.1136/bmjgh-2016-000243. ISSN 2059-7908. PMC 5435270. PMID 28589028.

 "172 countries and multiple candidate vaccines engaged in COVID-19 Vaccine Global Access Facility". GAVI. 4 September 2020. Archived from the original on 16 September 2020. Retrieved 15 September 2020.

 "UNICEF to lead procurement and supply of COVID-19 vaccines in world's largest and fastest ever operation of its kind". UNICEF. 4 September 2020. Archived from the original on 16 September 2020. Retrieved 15 September 2020.

 Cook E (4 September 2020). "UNICEF to lead supply chain for COVID-19 vaccine". Manufacturing. Archived from the original on 1 November 2020. Retrieved 13 September 2020.

 Hessel, Luc (2009). "Pandemic influenza vaccines: meeting the supply, distribution and deployment challenges". Influenza and Other Respiratory Viruses. 3 (4): 165–70. doi:10.1111/j.1750-2659.2009.00085.x. ISSN 1750-2640. PMC 4634681. PMID 19627373.

 "Vaccine management and logistics support". World Health Organization. 2020. Archived from the original on 13 September 2020. Retrieved 14 September 2020.

 Jarrett, Stephen; Yang, Lingjiang; Pagliusi, Sonia (9 June 2020). "Roadmap for strengthening the vaccine supply chain in emerging countries: Manufacturers' perspectives". Vaccine X. 5: 100068. doi:10.1016/j.jvacx.2020.100068. ISSN 2590-1362. PMC 7394771. PMID 32775997.

 Lloyd, John; Cheyne, James (2017). "The origins of the vaccine cold chain and a glimpse of the future". Vaccine. 35 (17): 2115–20. doi:10.1016/j.vaccine.2016.11.097. ISSN 0264-410X. PMID 28364918.

 "How can we make enough vaccine for 2 billion people?". World Economic Forum. 25 August 2020. Archived from the original on 16 September 2020. Retrieved 16 September 2020.

 "Coronavirus vaccine pre-orders worldwide top 5 billion". The Japan Times. 12 August 2020. Archived from the original on 20 September 2020. Retrieved 13 September 2020.

 C, Hannah (10 October 2020). "China Commits to Producing 600 Million Vaccine Doses by the End of 2020". Science Times. Archived from the original on 10 October 2020. Retrieved 10 October 2020.

 "Sinopharm says may be able to make over 1 billion coronavirus vaccine doses in 2021". Reuters. 20 October 2020. Retrieved 7 December 2020.

 "UAE company nears end of Chinese Covid-19 vaccine trial". Reuters. 8 October 2020. Retrieved 12 December 2020.

 "Sinovac secures $515 million to boost COVID-19 vaccine production". Reuters. 7 December 2020. Retrieved 7 December 2020.

 "Sao Paulo starts building production plant for China's Sinovac vaccine - governor". financialpost. Retrieved 12 December 2020.

 hermesauto (12 October 2020). "Indonesia aims to start administering coronavirus vaccines in early November". The Straits Times. Retrieved 12 December 2020.

 Molteni M (26 June 2020). "Vaccine makers turn to microchip tech to beat glass shortages". Wired. Archived from the original on 16 September 2020. Retrieved 17 September 2020.

 Kansteiner F (8 July 2020). "With COVID-19 vaccines coming, SiO2 injects $163M into vial production plant". FiercePharma, Questex LLC. Archived from the original on 5 October 2020. Retrieved 17 September 2020.

 Burger L, Blamont M (11 June 2020). "Bottlenecks? Glass vial makers prepare for COVID-19 vaccine". Reuters. Archived from the original on 29 September 2020. Retrieved 17 September 2020.

 Kaplan DA (7 July 2020). "3 applications for RFID in the fight against COVID-19". Supply Chain Dive. Archived from the original on 2 October 2020. Retrieved 17 September 2020.

 Brooks, Kristin (3 November 2020). "Ramping Up COVID-19 Vaccine Fill and Finish Capacity". Contract Pharma. Retrieved 25 November 2020.

 "Swiss factory rushes to prepare for Moderna Covid-19 vaccine". SwissInfo. 7 October 2020. Retrieved 1 November 2020.

 Kartoglu, Umit; Milstien, Julie (28 May 2014). "Tools and approaches to ensure quality of vaccines throughout the cold chain". Expert Review of Vaccines. 13 (7): 843–54. doi:10.1586/14760584.2014.923761. ISSN 1476-0584. PMC 4743593. PMID 24865112.

 Hanson, Celina M.; George, Anupa M.; Sawadogo, Adama; Schreiber, Benjamin (19 April 2017). "Is freezing in the vaccine cold chain an ongoing issue? A literature review". Vaccine. 35 (17): 2127–33. doi:10.1016/j.vaccine.2016.09.070. ISSN 0264-410X. PMID 28364920.

 "China's Sinopharm vaccine 86% effective, say United Arab Emirates officials | CBC News". CBC. Retrieved 11 December 2020.

 "CoronaVac: Doses will come from China on nine flights and can..." AlKhaleej Today (in Arabic). 1 November 2020. Retrieved 15 November 2020.

 "Moderna Announces Longer Shelf Life for its COVID-19 Vaccine Candidate at Refrigerated Temperatures". Moderna, Inc. (Press release). 16 November 2020. Retrieved 17 December 2020.

 Blankenship K (28 August 2020). "Pfizer, Moderna's coronavirus shot rollouts could freeze up, experts say, citing cold-storage needs". FiercePharma, Questex LLC. Retrieved 11 November 2020.

 O'Donnell C (9 November 2020). "Why Pfizer's ultra-cold COVID-19 vaccine will not be at the local pharmacy any time soon". Reuters. Retrieved 11 November 2020.

 Weise E (6 September 2020). "'Mind-bogglingly complex': Here's what we know about how COVID-19 vaccine will be distributed when it's approved". USA Today. Archived from the original on 12 September 2020. Retrieved 13 September 2020.

 Durbha M (29 June 2020). "The extra mile: preparing a supply chain for a COVID-19 vaccine". European Pharmaceutical Review. Archived from the original on 11 September 2020. Retrieved 13 September 2020.

 "The time to prepare for COVID-19 vaccine transport is now". International Air Transport Association. 9 September 2020. Archived from the original on 12 September 2020. Retrieved 13 September 2020.

 Paul J (9 December 2020). "Colorado's final coronavirus vaccine preparations include practicing for high-stakes delivery road trips". The Colorado Sun. Retrieved 11 December 2020.

 Chokshi, Niraj (10 December 2020). "Airlines Gear Up to Transport Vaccines That Could Revive Travel". The New York Times. Retrieved 11 December 2020.

 "COVID-19-related trafficking of medical products as a threat to public health" (PDF). United Nations Office on Drugs and Crime. 2020. Archived (PDF) from the original on 19 September 2020. Retrieved 16 September 2020.

 Castle S, Peltier E (7 December 2020). "After Botched Covid Response, U.K. Tackles Giant Vaccine Rollout". The New York Times. Retrieved 11 December 2020.

 Kohler JC, Dimancesco D (3 February 2020). "The risk of corruption in public pharmaceutical procurement: how anti-corruption, transparency and accountability measures may reduce this risk". Global Health Action. 13 (sup1): 1694745. doi:10.1080/16549716.2019.1694745. ISSN 1654-9716. PMC 7170361. PMID 32194011.

 Subramanian S (13 August 2020). "Biometric tracking can ensure billions have immunity against Covid-19". Bloomberg Businessweek. Archived from the original on 16 September 2020. Retrieved 16 September 2020.

 "INTERPOL warns of organized crime threat to COVID-19 vaccines". Interpol (Orange Notice). Retrieved 10 December 2020.

 "Effective Vaccine Management (EVM) Initiative:Vaccine Management Handbook". World Health Organization. 9 September 2020. Archived from the original on 5 October 2018. Retrieved 16 September 2020.

 Azar A (4 February 2020). "Notice of Declaration under the Public Readiness and Emergency Preparedness Act for medical countermeasures against COVID-19". Archived from the original on 25 April 2020. Retrieved 22 April 2020.

 Kertscher T (23 January 2020). "No, there is no vaccine for the Wuhan coronavirus". PolitiFact. Poynter Institute. Archived from the original on 7 February 2020. Retrieved 7 February 2020.

 McDonald J (24 January 2020). "Social Media Posts Spread Bogus Coronavirus Conspiracy Theory". FactCheck.org. Annenberg Public Policy Center. Archived from the original on 6 February 2020. Retrieved 8 February 2020.

 "Warning Letter – North Coast Biologics – MARCS-CMS 607532". U.S. Food and Drug Administration (FDA). 21 May 2020. Archived from the original on 26 May 2020. Retrieved 23 May 2020.

 Herper M (15 December 2020). "Inside the frantic and secretive sprint to name the Covid-19 vaccines". Stat. Retrieved 19 December 2020.

 Bird S (14 November 2020). "Trademark filings offer tantalising glimpse of coronavirus vaccine's name". The Telegraph. Retrieved 19 December 2020.

Footnotes

 With a steady supply of dry ice, the Pfizer-designed containers can insulate the vaccine for up to a month.[384]

Further reading

Vogel, Patric U. B. (2020). COVID-19 : Suche nach einem Impfstoff. Essentials. Wiesbaden: Springer Fachmedien Wiesbaden GmbH. doi:10.1007/978-3-658-31340-1. ISBN 978-3-658-31340-1. OCLC 1199717422.

Funk CD, Laferrière C, Ardakani A (2020). "A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic". Front Pharmacol. 11: 937. doi:10.3389/fphar.2020.00937. PMC 7317023. PMID 32636754.

Johnson CY, Mufson S (11 June 2020). "Can old vaccines from science's medicine cabinet ward off coronavirus?". The Washington Post.

"Development and Licensure of Vaccines to Prevent COVID-19: Guidance for Industry" (PDF). U.S. Food and Drug Administration (FDA). June 2020. Lay summary.

Zimmer C, Sheikh K, Weiland N (20 May 2020). "A New Entry in the Race for a Coronavirus Vaccine: Hope". The New York Times.

Haelle, Tara (12 December 2020). "Every Covid-19 Vaccine Question You'll Ever Have, Answered". Medium. Retrieved 12 December 2020.

External links

Wikiquote has quotations related to: COVID-19 vaccine

"Coronavirus Vaccine Tracker". The New York Times.

COVID-19 vaccine tracker, Regulatory Focus

"STAT's Covid-19 Drugs and Vaccines Tracker". Stat.

"Biopharma Leaders Unite to Stand with Science" (Press release). 8 September 2020 – via Business Wire.

"Protocol mRNA-1273-P301" (PDF). Moderna.

"Protocol C4591001 PF-07302048 (BNT162 RNA-Based COVID-19 Vaccines)" (PDF). Pfizer.

"Protocol AZD1222 – D8110C00001" (PDF). AstraZeneca.

"Protocol VAC31518COV3001; Phase 3" (PDF). Janssen Vaccines & Prevention.

Levine, Hallie (23 September 2020). "The 5 Stages of COVID-19 Vaccine Development: What You Need to Know About How a Clinical Trial Works". Johnson & Johnson.

"COVID-19 vaccines: development, evaluation, approval and monitoring". European Medicines Agency.

"Vaccine Development – 101". U.S. Food and Drug Administration (FDA).





 

msdogfood@hotmail.com